Počet záznamů: 1
Inhibitory effects of unmethylated CpG oligodeoxynucleotides on MHC class I-deficient and -proficient HPV16-associated tumours
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SYSNO ASEP 0024481 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Inhibitory effects of unmethylated CpG oligodeoxynucleotides on MHC class I-deficient and -proficient HPV16-associated tumours Překlad názvu Inhibiční účinky nemethylovaných CpG oligodeoxynukleotidů na MHC I+ a MHC I- nádory vyvolané HPV16 Tvůrce(i) Reiniš, Milan (UMG-J) RID
Šímová, Jana (UMG-J) RID
Bubeník, Jan (UMG-J)Zdroj.dok. International Journal of Cancer. - : Wiley - ISSN 0020-7136
Roč. 118, č. 7 (2006), s. 1836-1842Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova HPV16 ; immunotherapy ; CpG oligodeoxynucleotides Vědní obor RIV EC - Imunologie CEP GA301/04/0492 GA ČR - Grantová agentura ČR CEZ AV0Z50520514 - UMG-J (2005-2011) Anotace Unmethylated oligodeoxynucleotides containing guanine-cytidine dimers (CpG ODN) were described as potent inducers of selected antitumour immune responses and the immunotherapeutic efficacy of CpG ODN has been examined either alone or as a vaccine adjuvant. We hypothesized that CpG ODN therapy could be effective in immunotherapy of conventional MHC class I+ tumours as well as tumours that lost MHC class I expression during their progression. We employed the animal model resembling MHC class I+ and I- human papilloma virus 16-associated tumours. Immunotherapy with CpG ODN 1826 significantly reduced the growth of MHC class I-proficient and -deficient tumours. We also demonstrated that CpG ODN 1585, which indirectly activate natural killer cells, induced regression of MHC class I- tumours but not I+ tumours. This infers that synthetic CpG ODN have a potential for therapy of MHC class I+ and I- tumours and thus could be also used against tumours with down-regulated MHC class I expression. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2006
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