Počet záznamů: 1
Sperm mitochondria dysfunction in response to testicular cancer
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SYSNO ASEP 0582890 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Sperm mitochondria dysfunction in response to testicular cancer Tvůrce(i) Qasemi, Maryam (BTO-N) RID, ORCID
Sur, Vishma Pratap (BTO-N)
Šimoník, Ondřej (BTO-N)
Postlerová, Pavla (BTO-N) ORCID, RID
Skrobanek, P. (CZ)
Hradec, T. (CZ)
Boublikova, L. (CZ)
Zámečník, L. (CZ)
Buchler, T. (CZ)
Neužil, Jiří (BTO-N) RID
Komrsková, Kateřina (BTO-N) ORCIDCelkový počet autorů 11 Zdroj.dok. European Journal of Clinical Investigation. - : Wiley - ISSN 0014-2972
DEC 2023, 2023-12-17 (2023)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova germ-cell tumors ; mitochondrial dysfunction ; oxphos ; sperm pathology Vědní obor RIV FE - Ostatní obory vnitřního lékařství Obor OECD General and internal medicine CEP NU20-03-00309 GA MZd - Ministerstvo zdravotnictví ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 001116965300001 EID SCOPUS 85178963674 DOI 10.1111/eci.14146 Anotace Testicular cancer is the most common form of cancer in young men of reproductive age and its incidence is increasing globally. With the currently successful treatment and 95% survival rate, there is a need for deeper understanding of testicular cancer-related infertility. Most patients with testicular cancer experience semen abnormalities prior to cancer therapy. However, the exact mechanism of the effect of testicular cancer on sperm anomalies is not known. Mitochondria are organelles that play a crucial role in both tumorigenesis and spermatogenesis and their malfunction may be an important factor resulting in sperm abnormalities in testicular cancer patients. Within the scope of this review, we will discuss current knowledge of testicular cancer-related alterations in the ATP production pathway, a possible pathophysiological switch from oxidative phosphorylation (OXPHOS) to glycolysis, as well as the role of oxidative stress promoting sperm dysfunction. In this regard, the review provides a summary of the impact of testicular cancer on sperm quality as a possible consequence of impaired mitochondrial function including the energy metabolic pathways that are known to be altered in the sperm of testicular cancer patients. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2024 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1111/eci.14146
Počet záznamů: 1