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Pitfalls of Mitochondrial Redox Signaling Research
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SYSNO ASEP 0576981 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Pitfalls of Mitochondrial Redox Signaling Research Tvůrce(i) Ježek, Petr (FGU-C) RID, ORCID Číslo článku 1696 Zdroj.dok. Antioxidants. - : MDPI
Roč. 12, č. 9 (2023)Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova redox signaling from mitochondria ; matrix H2O2 release ; H2O2 release into intracristal space ; cytosolic H2O2 release ; redox buffers ; peroxiredoxins ; redox-sensitive probes ; MnSOD Obor OECD Physiology (including cytology) CEP GA21-01205S GA ČR - Grantová agentura ČR LX22NPO5104 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 001079866700001 EID SCOPUS 85172211556 DOI 10.3390/antiox12091696 Anotace Redox signaling from mitochondria (mt) to the cytosol and plasma membrane (PM) has been scarcely reported, such as in the case of hypoxic cell adaptation or (2-oxo-) 2-keto-isocaproate (KIC) beta-like-oxidation stimulating insulin secretion in pancreatic beta-cells. Mutual redox state influence between mitochondrial major compartments, the matrix and the intracristal space, and the cytosol is therefore derived theoretically in this article to predict possible conditions, when mt-to-cytosol and mt-to-PM signals may occur, as well as conditions in which the cytosolic redox signaling is not overwhelmed by the mitochondrial antioxidant capacity. Possible peroxiredoxin 3 participation in mt-to-cytosol redox signaling is discussed, as well as another specific case, whereby mitochondrial superoxide release is diminished, whereas the matrix MnSOD is activated. As a result, the enhanced conversion to H2O2 allows H2O2 diffusion into the cytosol, where it could be a predominant component of the H(2)O(2 )release. In both of these ways, mt-to-cytosol and mt-to-PM signals may be realized. Finally, the use of redox-sensitive probes is discussed, which disturb redox equilibria, and hence add a surplus redox-buffering to the compartment, where they are localized. Specifically, when attempts to quantify net H2O2 fluxes are to be made, this should be taken into account. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/2076-3921/12/9/1696
Počet záznamů: 1