Počet záznamů: 1
Reverting to a Healthy Diet during Lactation Normalizes Maternal Milk Lipid Content of Diet-Induced Obese Rats and Prevents Early Alterations in the Plasma Lipidome of the Offspring
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SYSNO ASEP 0561068 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Reverting to a Healthy Diet during Lactation Normalizes Maternal Milk Lipid Content of Diet-Induced Obese Rats and Prevents Early Alterations in the Plasma Lipidome of the Offspring Tvůrce(i) Castillo, P. (ES)
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Kopecký, Jan (FGU-C) RID, ORCID
Pomar, C. A. (ES)
Palou, A. (ES)
Palou, M. (ES)
Picó, C. (ES)Číslo článku 2200204 Zdroj.dok. Molecular Nutrition & Food Research. - : Wiley - ISSN 1613-4125
Roč. 66, č. 17 (2022)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova inflammation ; lipidomics ; milk composition ; suckling ; western diet Obor OECD Endocrinology and metabolism (including diabetes, hormones) Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000824139600001 EID SCOPUS 85133979136 DOI 10.1002/mnfr.202200204 Anotace Scope This study aims to assess in rats whether normalizing maternal diet during lactation prevents the harmful effects of western diet (WD) consumption during the whole perinatal period on the lipidomic profile in maternal milk and offspring plasma. Methods and Results Control dams (CON-dams), fed with standard diet (SD), WD-dams, fed with WD prior and during gestation and lactation, and reversion dams (REV-dams), fed as WD-dams but moved to SD during lactation are followed. Lipidomic analysis is performed in milk and plasma samples from pups. Milk of WD-dams presents a different triacylglycerol composition and free fatty acid (FA) profile compared to CON-dams, including an increased ratio of pro-inflammatory to anti-inflammatory long-chain polyunsaturated FA. Such alterations, which are also present in the plasma of their offspring, are widely reversed in the milk of REV-dams and the plasma of their pups. This is related with the recovery of control adiponectin expression levels in the mammary gland, and the presence of decreased expression of pro-inflammatory factors. Conclusion Implementing a healthy diet during lactation prevents early alterations in the plasma lipidome of pups associated to the maternal intake of an obesogenic diet, which may be related to the normalization of milk lipid content and the inflammatory state in the mammary gland. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1002/mnfr.202200204
Počet záznamů: 1