Počet záznamů: 1

The Effect of Sulforaphane on Perinatal Hypoxic-Ischemic Brain Injury in Rats

SYSNO ASEP	0560055
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	The Effect of Sulforaphane on Perinatal Hypoxic-Ischemic Brain Injury in Rats
Tvůrce(i)	Kapoor, Sonam (FGU-C)_ORCID Kala, David (FGU-C) Svoboda, Jan (FGU-C) Daněk, Jan (FGU-C) Faridová, Adéla (FGU-C)_ORCID Brnoliaková, Z. (SK) Mikulecká, Anna (FGU-C)_{RID, ORCID} Folbergrová, Jaroslava (FGU-C)_RID Otáhal, Jakub (FGU-C)_{RID, ORCID, SAI}
Celkový počet autorů	9
Zdroj.dok.	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 71, č. 3 (2022), s. 401-411
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	CZ - Česká republika
Klíč. slova	perinatal hypoxic-ischemic insult ; rat ; FDG-PET ; sulforaphane ; neuronal damage ; motor impairment
Obor OECD	Neurosciences (including psychophysiology
CEP	GA18-07908S GA ČR - Grantová agentura ČR
	LM2018129 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	GA22-28265S GA ČR - Grantová agentura ČR
Způsob publikování	Open access
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000834626200006
EID SCOPUS	85135419620
DOI	10.33549/physiolres.934878
Anotace	Perinatal hypoxic-ischemic insult (HII) is one of the main devastating causes of morbidity and mortality in newborns. HII induces brain injury which evolves to neurological sequelae later in life. Hypothermia is the only therapeutic approach available capable of diminishing brain impairment after HII. Finding a novel therapeutic method to reduce the severity of brain injury and its consequences is critical in neonatology. The present paper aimed to evaluate the effect of sulforaphane (SFN) pre-treatment on glucose metabolism, neurodegeneration, and functional outcome at the acute, sub-acute, and sub-chronic time intervals in the experimental model of perinatal hypoxic-ischemic insult in rats. To estimate the effect of SFN on brain glucose uptake we have performed 18F-deoxyglucose (FDG) ??CT/PET. The activity of FDG was determined in the hippocampus and sensorimotor cortex. Neurodegeneration was assessed by histological analysis of Nissl-stained brain sections. To investigate functional outcomes a battery of behavioral tests was employed. We have shown that although SFN possesses a protective effect on glucose uptake in the ischemic hippocampus 24 h and 1 week after HII, no effect has been observed in the motor cortex. We have further shown that the ischemic hippocampal formation tends to be thinner in HIE and SFN treatment tends to reverse this pattern. We have observed subtle chronic movement deficit after HII detected by ladder rung walking test with no protective effect of SFN. SFN should be thus considered as a potent neuroprotective drug with the capability to interfere with pathophysiological processes triggered by perinatal hypoxic-ischemic insult.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2023
Elektronická adresa	https://www.biomed.cas.cz/physiolres/pdf/2022/71_401.pdf

Počet záznamů: 1