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Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength
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SYSNO ASEP 0559150 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength Tvůrce(i) Dodda, J. M. (CZ)
Azar, M. G. (CZ)
Bělský, P. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Brož, Antonín (FGU-C) RID, ORCID, SAI
Bačáková, Lucie (FGU-C) RID, ORCID
Kadlec, J. (CZ)
Remiš, T. (CZ)Zdroj.dok. Cellulose. - : Springer - ISSN 0969-0239
Roč. 29, č. 12 (2022), s. 6697-6717Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova nulticomponent hydrogel ; cellulose/starch ; chitosan Obor OECD Polymer science Vědní obor RIV – spolupráce Ústav makromolekulární chemie - Makromolekulární chemie
Fyziologický ústav - Biotechnologie a bionikaCEP GA20-01641S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 ; FGU-C - RVO:67985823 UT WOS 000815422900001 EID SCOPUS 85132706794 DOI 10.1007/s10570-022-04686-4 Anotace Fabricating mechanically strong hydrogels that can withstand the conditions in internal tissues is a challenging task. We have designed hydrogels based on multicomponent systems by combining chitosan, starch/cellulose, PVA, and PEDOT:PSS via one-pot synthesis. The starch-based hydrogels were homogeneous, while the cellulose-based hydrogels showed the presence of cellulose micro- and nanofibers. The cellulose-based hydrogels demonstrated a swelling ratio between 121 and 156%, while the starch-based hydrogels showed higher values, from 234 to 280%. Tensile tests indicated that the presence of starch in the hydrogels provided high flexibility (strain at break > 300%), while combination with cellulose led to the formation of stiffer hydrogels (elastic moduli 3.9–6.6 MPa). The ultimate tensile strength for both types of hydrogels was similar (2.8–3.9 MPa). The adhesion and growth of human osteoblast-like SAOS-2 cells was higher on hydrogels with cellulose than on hydrogels with starch, and was higher on hydrogels with PEDOT:PSS than on hydrogels without this polymer. The metabolic activity of cells cultivated for 3 days in the hydrogel infusions indicated that no acutely toxic compounds were released. This is promising for further possible applications of these hydrogels in tissue engineering or in wound dressings. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://link.springer.com/article/10.1007/s10570-022-04686-4
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