Počet záznamů: 1
Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose
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SYSNO ASEP 0557065 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose Tvůrce(i) Senko, A. N. (DE)
Overall, R. W. (DE)
Šilhavý, Jan (FGU-C) RID, ORCID
Mlejnek, Petr (FGU-C) RID, ORCID
Malínská, H. (CZ)
Hüttl, M. (CZ)
Marková, I. (CZ)
Fabel, K. S. (DE)
Lu, L. (US)
Stuchlík, Aleš (FGU-C) RID, ORCID
Williams, R. W. (US)
Pravenec, Michal (FGU-C) RID, ORCID
Kempermann, G. (DE)Celkový počet autorů 13 Číslo článku e1009638 Zdroj.dok. PLoS Genetics. - : Public Library of Science - ISSN 1553-7404
Roč. 18, č. 4 (2022)Poč.str. 35 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova spontaneously hypertensive-rats ; triple t complex ; ataxia-telangiectasia ; sphingosine 1-phosphate ; mammalian target ; candidate genes ; nervous-system ; cell-survival ; igf-i ; expression Obor OECD Genetics and heredity (medical genetics to be 3) CEP GA20-00939S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000780213300003 EID SCOPUS 85128526029 DOI 10.1371/journal.pgen.1009638 Anotace Metabolic and neurological disorders are often comorbid, suggesting that biological pathways which orchestrate peripheral homeostasis and the integrity of the nervous system intersect. The genetic architecture behind these relationships is still poorly described, in part because molecular processes in the human brain are very difficult to study. We thus used a rodent genetic reference population to investigate links between adult hippocampal neurogenesis-a cellular plasticity mechanism important for learning flexibility-and metabolism. We measured adult neurogenesis in the family of 30 HXB/BXH rat recombinant inbred strains, who are characterised by stable differences in metabolism, behaviour, and gene expression levels.Because DNA variants affecting distinct traits segregated into different members of the family, it was possible to determine which of the previously published phenotypes correlated to adult neurogenesis due to shared genomic sequence. We found that expression levels of Tti2-a part of a specialised protein chaperone complex regulating stability of PIKK kinases-were concomitantly influencing adult neurogenesis and serum glucose levels. In human populations hundreds of genomic variants regulate TTI2 expression, potentially affecting brain function and glucose homeostasis. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1371/journal.pgen.1009638
Počet záznamů: 1