Počet záznamů: 1  

Self-assembly, drug encapsulation, and cellular uptake of block and gradient copolymers of 2-methyl-2-oxazine and 2-n-propyl/butyl-2-oxazoline

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    SYSNO ASEP0549608
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevSelf-assembly, drug encapsulation, and cellular uptake of block and gradient copolymers of 2-methyl-2-oxazine and 2-n-propyl/butyl-2-oxazoline
    Tvůrce(i) Babuka, David (UMCH-V)
    Kolouchová, Kristýna (UMCH-V) ORCID, RID
    Loukotová, Lenka (UMCH-V) RID, ORCID
    Sedláček, O. (CZ)
    Groborz, Ondřej (UMCH-V) ORCID, RID
    Škarková, A. (CZ)
    Zhigunov, Alexander (UMCH-V) RID, ORCID
    Pavlova, Ewa (UMCH-V) RID
    Hoogenboom, R. (BE)
    Hrubý, Martin (UMCH-V) RID, ORCID
    Štěpánek, Petr (UMCH-V) RID, ORCID
    Zdroj.dok.Macromolecules. - : AMER CHEMICAL SOC - ISSN 0024-9297
    Roč. 54, č. 23 (2021), s. 10667-10681
    Poč.str.15 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovapolyoxazoline ; gradient polymer ; block polymer
    Vědní obor RIVCD - Makromolekulární chemie
    Obor OECDPolymer science
    CEPGA19-01602S GA ČR - Grantová agentura ČR
    Způsob publikováníOmezený přístup
    Institucionální podporaUMCH-V - RVO:61389013
    UT WOS000752886100004
    EID SCOPUS85120725708
    DOI10.1021/acs.macromol.1c01794
    AnotaceSelf-assembled amphiphilic polymers have been extensively studied for various biomedical applications, as they show advantageous properties for diagnosis and therapy. In this work, we extensively compared amphiphilic copolymers of the hydrophilic monomer 2-methyl-2-oxazine (MeOzi) and the thermoresponsive or hydrophobic monomers 2-propyl-2-oxazoline (PrOx) or 2-butyl-2-oxazoline (BuOx) in both block and gradient monomer distributions. Such a head-to-head comparison between block and gradient copolymers, which has thus far been mostly missing in the available literature, should provide important insight into the differences and similarities between these two architectures. We investigated the properties of our polymers using a wide array of analytical methods, including dynamic light scattering (DLS), small-angle neutron (SANS) and X-ray scattering (SAXS), one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy, transmission electron microscopy (TEM), drug loading (DL), cellular uptake, and cytotoxicity studies. Most of the studied polymers formed self-assembled nanoparticles, but their properties varied with the monomer ratio, polymer length, and polymer architecture, and these factors could be used to fine-tune the properties of the polymer to meet the demands of the desired application. Both block and gradient copolymers showed similar critical association concentrations and DL properties for the antituberculosis drug rifampicin. Finally, we confirmed that the nanoparticles could be internalized by macrophages, which indicates great potential for the utilization of these nanoparticles in drug delivery.
    PracovištěÚstav makromolekulární chemie
    KontaktEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Rok sběru2022
    Elektronická adresahttps://pubs.acs.org/doi/10.1021/acs.macromol.1c01794
Počet záznamů: 1