Počet záznamů: 1  

Neurodegenerative Diseases Biomarkers

  1. 1.
    SYSNO ASEP0548440
    Druh ASEPM - Kapitola v monografii
    Zařazení RIVC - Kapitola v knize
    NázevValidation of Diffusion Kurtosis Imaging as an Early-Stage Biomarker of Parkinson’s Disease in Animal Models
    Tvůrce(i) Khairnar, A. (IN)
    Dražanová, Eva (UPT-D) RID, ORCID, SAI
    Szabó, N. (HU)
    Rudá-Kučerová, J. (CZ)
    Zdroj.dok.Neurodegenerative Diseases Biomarkers. - New York : Humana, 2022 / Peplow P. V. ; Martinez B. ; Gennarelli T. A. - ISBN 978-1-0716-1711-3
    Rozsah strans. 429-455
    Poč.str.27 s.
    Poč.str.knihy565
    Forma vydáníTištěná - P
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaDiffusion kurtosis imaging ; Diffusion tensor imaging ; Magnetic resonance imaging ; Methamphetamine ; Microstructural changes ; Neurodegeneration ; α-Synuclein ; TNWT-61 Mice
    Vědní obor RIVFH - Neurologie, neurochirurgie, neurovědy
    Obor OECDNeurosciences (including psychophysiology
    CEPLM2015062 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    EF16_013/0001775 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    Institucionální podporaUPT-D - RVO:68081731
    EID SCOPUS85117525934
    DOI10.1007/978-1-0716-1712-0_18
    AnotaceDiffusion kurtosis imaging (DKI), which is a mathematical extension of diffusion tensor imaging (DTI), assesses non-Gaussian water diffusion in the brain. DKI proved to be effective in supporting the diagnosis of different neurodegenerative disorders. Its sensitively detects microstructural changes in the brain induced by either protein accumulation, glial cell activation or neurodegeneration as observed in mouse models of Parkinson’s disease. We applied two experimental models of Parkinson’s disease to validate the diagnostic utility of DKI in early and late stage of disease pathology. We present two DKI analysis methods: (1) tract based spatial statistics (TBSS), which is a hypothesis independent data driven approach intended to evaluate white matter changes, and (2) region of interest (ROI) based analysis based on hypothesis of ROIs relevant for Parkinson’s disease, which is specifically used for gray matter changes. The main aim of this chapter is to provide detailed information of how to perform the DKI imaging acquisition and analysis in the mouse brain, which can be, to some extent translated to humans.
    PracovištěÚstav přístrojové techniky
    KontaktMartina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178
    Rok sběru2023
    Elektronická adresahttps://link.springer.com/protocol/10.1007%2F978-1-0716-1712-0_18
Počet záznamů: 1