Počet záznamů: 1
Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms
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SYSNO ASEP 0543461 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms Tvůrce(i) Lemberg, M. K. (DE)
Stříšovský, Kvido (UOCHB-X) RID, ORCIDZdroj.dok. Molecular Cell. - : Cell Press - ISSN 1097-2765
Roč. 81, č. 12 (2021), s. 2507-2519Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova reticulum-associated degradation ; signal peptide peptidase ; class I molecules Obor OECD Biochemistry and molecular biology CEP GA18-09556S GA ČR - Grantová agentura ČR GA20-25331S GA ČR - Grantová agentura ČR EF16_019/0000729 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000674490700005 EID SCOPUS 85107984069 DOI 10.1016/j.molcel.2021.05.004 Anotace Protein homeostasis mechanisms are fundamentally important to match cellular needs and to counteract stress conditions. A fundamental challenge is to understand how defective proteins are recognized and extracted from cellular organelles to be degraded in the cytoplasm. The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway is the best-understood organellar protein quality control system. Here, we review new insights into the mechanism of recognition and retrotranslocation of client proteins in ERAD. In addition to the membrane-integral ERAD E3 ubiquitin ligases, we highlight one protein family that is remarkably often involved in various aspects of membrane protein quality control and protein dislocation: the rhomboid superfamily, which includes derlins and intramembrane serine proteases. Rhomboid-like proteins have been found to control protein homeostasis in the ER, but also in other eukaryotic organelles and in bacteria, pointing toward conserved principles of membrane protein quality control across organelles and evolution. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2022 Elektronická adresa https://doi.org/10.1016/j.molcel.2021.05.004
Počet záznamů: 1