Počet záznamů: 1
Circadian regulation of transporter expression and implications for drug disposition
- 1.
SYSNO ASEP 0542597 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Circadian regulation of transporter expression and implications for drug disposition Tvůrce(i) Pácha, Jiří (FGU-C) RID, ORCID
Balounová, Kateřina (FGU-C) RID, ORCID
Soták, M. (SE)Zdroj.dok. Expert Opinion on Drug Metabolism & Toxicology. - : Taylor & Francis - ISSN 1742-5255
Roč. 17, č. 4 (2021), s. 425-439Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova drug transport ; drug elimination ; circadian rhythms ; solute carriers ; ATP-binding cassette transporters ; liver ; intestine ; kidney Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GA18-02993S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000604653900001 EID SCOPUS 85098689413 DOI 10.1080/17425255.2021.1868438 Anotace Introduction: Solute Carrier (SLC) and ATP-binding cassette (ABC) transporters expressed in the intestine, liver, and kidney determine the absorption, distribution, and excretion of drugs. In addition, most molecular and cellular processes show circadian rhythmicity controlled by circadian clocks that leads to diurnal variations in the pharmacokinetics and pharmacodynamics of many drugs and affects their therapeutic efficacy and toxicity.Area covered: This review provides an overview of the current knowledge on the circadian rhythmicity of drug transporters and the molecular mechanisms of their circadian control. Evidence for coupling drug transporters to circadian oscillators and the plausible candidates conveying circadian clock signals to target drug transporters, particularly transcription factors operating as the output of clock genes, is discussed.Expert opinion: The circadian machinery has been demonstrated to interact with the uptake and efflux of various drug transporters. The evidence supports the concept that diurnal changes that affect drug transporters may influence the pharmacokinetics of the drugs. However, more systematic studies are required to better define the timing of pharmacologically important drug transporter regulation and determine tissue- and sex-dependent differences. Finally, the transfer of knowledge based on the results and conclusions obtained primarily from animal models will require careful validation before it is applied to humans. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2022 Elektronická adresa https://doi.org/10.1080/17425255.2021.1868438
Počet záznamů: 1