Počet záznamů: 1  

Circadian regulation of transporter expression and implications for drug disposition

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    SYSNO ASEP0542597
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevCircadian regulation of transporter expression and implications for drug disposition
    Tvůrce(i) Pácha, Jiří (FGU-C) RID, ORCID
    Balounová, Kateřina (FGU-C) RID, ORCID
    Soták, M. (SE)
    Zdroj.dok.Expert Opinion on Drug Metabolism & Toxicology - ISSN 1742-5255
    Roč. 17, č. 4 (2021), s. 425-439
    Poč.str.15 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovadrug transport ; drug elimination ; circadian rhythms ; solute carriers ; ATP-binding cassette transporters ; liver ; intestine ; kidney
    Vědní obor RIVED - Fyziologie
    Obor OECDPhysiology (including cytology)
    CEPGA18-02993S GA ČR - Grantová agentura ČR
    Způsob publikováníOmezený přístup
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000604653900001
    EID SCOPUS85098689413
    AnotaceIntroduction: Solute Carrier (SLC) and ATP-binding cassette (ABC) transporters expressed in the intestine, liver, and kidney determine the absorption, distribution, and excretion of drugs. In addition, most molecular and cellular processes show circadian rhythmicity controlled by circadian clocks that leads to diurnal variations in the pharmacokinetics and pharmacodynamics of many drugs and affects their therapeutic efficacy and toxicity.Area covered: This review provides an overview of the current knowledge on the circadian rhythmicity of drug transporters and the molecular mechanisms of their circadian control. Evidence for coupling drug transporters to circadian oscillators and the plausible candidates conveying circadian clock signals to target drug transporters, particularly transcription factors operating as the output of clock genes, is discussed.Expert opinion: The circadian machinery has been demonstrated to interact with the uptake and efflux of various drug transporters. The evidence supports the concept that diurnal changes that affect drug transporters may influence the pharmacokinetics of the drugs. However, more systematic studies are required to better define the timing of pharmacologically important drug transporter regulation and determine tissue- and sex-dependent differences. Finally, the transfer of knowledge based on the results and conclusions obtained primarily from animal models will require careful validation before it is applied to humans.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2022
    Elektronická adresahttps://doi.org/10.1080/17425255.2021.1868438
Počet záznamů: 1