Počet záznamů: 1

Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity

SYSNO ASEP	0541673
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity
Tvůrce(i)	Sistilli, Gabriella (FGU-C) Kalendová, Veronika (FGU-C)_{RID, ORCID} Čajka, Tomáš (FGU-C)_{RID, ORCID, SAI} Irodenko, Ilaria (FGU-C) Bardová, Kristina (FGU-C)_{RID, ORCID, SAI} Oseeva, Marina (FGU-C)_{ORCID, RID} Žáček, P. (CZ) Kroupová, Petra (FGU-C)_ORCID Horáková, Olga (FGU-C)_{RID, ORCID} Lackner, K. (AT) Gastaldelli, A. (IT) Kuda, Ondřej (FGU-C)_{RID, ORCID, SAI} Kopecký, Jan (FGU-C)_{RID, ORCID} Rossmeisl, Martin (FGU-C)_{RID, ORCID}
Číslo článku	437
Zdroj.dok.	Nutrients. - : MDPI Roč. 13, č. 2 (2021)
Poč.str.	24 s.
Jazyk dok.	eng - angličtina
Země vyd.	CH - Švýcarsko
Klíč. slova	NAFLD ; obesity ; omega-3 ; krill oil ; phospholipids ; high-fat diet ; C57BL/6N mice ; thermoneutral temperature
Vědní obor RIV	FB - Endokrinologie, diabetologie, metabolizmus, výživa
Obor OECD	Endocrinology and metabolism (including diabetes, hormones)
CEP	GA17-11027S GA ČR - Grantová agentura ČR
Způsob publikování	Open access
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000622893700001
EID SCOPUS	85099993828
DOI	10.3390/nu13020437
Anotace	Preclinical evidence suggests that n-3 fatty acids EPA and DHA (Omega-3) supplemented as phospholipids (PLs) may be more effective than triacylglycerols (TAGs) in reducing hepatic steatosis. To further test the ability of Omega-3 PLs to alleviate liver steatosis, we used a model of exacerbated non-alcoholic fatty liver disease based on high-fat feeding at thermoneutral temperature. Male C57BL/6N mice were fed for 24 weeks a lard-based diet given either alone (LHF) or supplemented with Omega-3 (30 mg/g diet) as PLs (krill oil, w3PL) or TAGs (Epax 3000TG concentrate, w3TG), which had a similar total content of EPA and DHA and their ratio. Substantial levels of TAG accumulation (similar to 250 mg/g) but relatively low inflammation/fibrosis levels were achieved in the livers of control LHF mice. Liver steatosis was reduced by >40% in the omega 3PL but not omega 3TG group, and plasma ALT levels were markedly reduced (by 68%) in omega 3PL mice as well. Krill oil administration also improved hepatic insulin sensitivity, and its effects were associated with high plasma adiponectin levels (150% of LHF mice) along with superior bioavailability of EPA, increased content of alkaloids stachydrine and trigonelline, suppression of lipogenic gene expression, and decreased diacylglycerol levels in the liver. This study reveals that in addition to Omega-3 PLs, other constituents of krill oil, such as alkaloids, may contribute to its strong antisteatotic effects in the liver.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2022
Elektronická adresa	https://www.mdpi.com/2072-6643/13/2/437

Počet záznamů: 1