Počet záznamů: 1
Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients
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SYSNO ASEP 0539306 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients Tvůrce(i) Vodenková, Soňa (UEM-P) ORCID, RID
Kroupa, Michal (UEM-P)
Polívková, Z. (CZ)
Musak, L. (SK)
Ambruš, M. (CZ)
Schneiderová, M. (CZ)
Kozevnikovová, R. (CZ)
Vodičková, Ludmila (UEM-P) RID
Rachakonda, S. (DE)
Hemminki, K. (DE)
Kumar, R. (DE)
Vodička, Pavel (UEM-P) RIDZdroj.dok. Oncology Reports - ISSN 1021-335X
Roč. 44, č. 5 (2020), s. 2219-2230Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GR - Řecko Klíč. slova structural chromosomal aberrations ; telomere length ; peripheral blood lymphocytes Vědní obor RIV FD - Onkologie a hematologie Obor OECD Oncology CEP GA18-09709S GA ČR - Grantová agentura ČR NV15-27580A GA MZd - Ministerstvo zdravotnictví Způsob publikování Omezený přístup Institucionální podpora UEM-P - RVO:68378041 UT WOS 000582501500039 EID SCOPUS 85092093899 DOI 10.3892/or.2020.7774 Anotace Accumulation of non-specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer-free control individuals were investigated. These results were then correlated with clinicopathological factors and follow-up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid-type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2021 Elektronická adresa https://www.spandidos-publications.com/10.3892/or.2020.7774
Počet záznamů: 1