Počet záznamů: 1

Colloidally stable P(DMA-AGME)-Ale-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ nanoparticles as a multimodal contrast agent for down- and upconversion luminescence, magnetic resonance imaging, and computed tomography

SYSNO ASEP	0537739
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Colloidally stable P(DMA-AGME)-Ale-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ nanoparticles as a multimodal contrast agent for down- and upconversion luminescence, magnetic resonance imaging, and computed tomography
Tvůrce(i)	Shapoval, Oleksandr (UMCH-V)_{ORCID, RID} Oleksa, Viktoriia (UMCH-V)_RID Šlouf, Miroslav (UMCH-V)_{RID, ORCID} Lobaz, Volodymyr (UMCH-V)_{RID, ORCID} Trhlíková, Olga (UMCH-V)_{RID, ORCID} Filipová, Marcela (UMCH-V)_{RID, ORCID} Janoušková, Olga (UMCH-V)_{RID, SAI, ORCID} Engstová, Hana (FGU-C)_{RID, ORCID} Pankrác, J. (CZ) Modrý, A. (CZ) Herynek, V. (CZ) Ježek, Petr (FGU-C)_{RID, ORCID} Šefc, L. (CZ) Horák, Daniel (UMCH-V)_{RID, ORCID}
Číslo článku	230
Zdroj.dok.	Nanomaterials. - : MDPI Roč. 11, č. 1 (2021)
Poč.str.	21 s.
Jazyk dok.	eng - angličtina
Země vyd.	CH - Švýcarsko
Klíč. slova	up-conversion luminescence ; down-conversion luminescence ; colloidal stability
Vědní obor RIV	CD - Makromolekulární chemie
Obor OECD	Polymer science
Vědní obor RIV – spolupráce	Fyziologický ústav - Morfologické obory a cytologie
CEP	GA19-00676S GA ČR - Grantová agentura ČR
	LM2018129 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	EF16_013/0001775 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	LTC19032 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Výzkumná infrastruktura	Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
Způsob publikování	Open access
Institucionální podpora	UMCH-V - RVO:61389013 ; FGU-C - RVO:67985823
UT WOS	000610663900001
EID SCOPUS	85100140596
DOI	10.3390/nano11010230
Anotace	Multimodal imaging, integrating several modalities including down- and up-conversion luminescence, T1- and T2(T2)-weighted MRI, and CT contrasting in one system, is very promising for improved diagnosis of severe medical disorders. To reach the goal, it is necessary to develop suitable nanoparticles that are highly colloidally stable in biologically relevant media. Here, hydrophilic poly(N,N-dimethylacrylamide-N-acryloylglycine methyl ester)-alendronate-[P(DMA-AGME)-Ale]-coated Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ nanoparticles were synthesized by a coprecipitation method in ethylene glycol (EG) followed by coating with the polymer. The particles were tho-roughly characterized by a dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray energy dispersive spectroscopy (EDAX), selected area electron diffraction (SAED), elemental ana-lysis and fluorescence spectroscopy. Aqueous particle dispersions exhibited excellent colloidal stability in water and physiological buffers. In vitro toxicity assessments suggested no or only mild toxicity of the surface-engineered Gd(Tb)F3:Tb3+(Gd3+),Yb3+,Nd3+ particles in a wide range of concentrations. Internalization of the particles by several types of cells, including HeLa, HF, HepG2, and INS, was confirmed by a down- and up-conversion confocal microscopy. Newly developed particles thus proved to be an efficient contrast agent for fluorescence imaging, T1- and T2(T2)-weighted magnetic resonance imaging (MRI), and computed tomography (CT).
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2022
Elektronická adresa	https://www.mdpi.com/2079-4991/11/1/230

Počet záznamů: 1