Počet záznamů: 1  

Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: a road from failure to success in clinical applications

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    SYSNO ASEP0537561
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAnalyzing the mechanisms of iron oxide nanoparticles interactions with cells: a road from failure to success in clinical applications
    Tvůrce(i) Frtús, Adam (FZU-D) ORCID
    Smolková, Barbora (FZU-D) ORCID
    Uzhytchak, Mariia (FZU-D) ORCID
    Lunova, Mariia (FZU-D) ORCID
    Jirsa, M. (CZ)
    Kubinová, Šárka (FZU-D) RID, ORCID
    Dejneka, Alexandr (FZU-D) RID, ORCID
    Lunov, Oleg (FZU-D) ORCID
    Celkový počet autorů8
    Zdroj.dok.Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
    Roč. 328, Dec (2020), s. 59-77
    Poč.str.19 s.
    Jazyk dok.eng - angličtina
    Země vyd.NL - Nizozemsko
    Klíč. slovairon oxide nanoparticles ; endocytosis ; magnetic resonance imaging ; cytotoxicity ; lysosomes ; apoptosis ; autophagy ; cancer
    Vědní obor RIVBO - Biofyzika
    Obor OECDBiophysics
    CEPLTC19040 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    Způsob publikováníOmezený přístup
    Institucionální podporaFZU-D - RVO:68378271
    UT WOS000600791600005
    EID SCOPUS85089899628
    DOI10.1016/j.jconrel.2020.08.036
    AnotaceIron oxide nanoparticles (IONPs) were the first generation of nanomaterials that reached real clinic use. Particularly, several IONPs-based magnetic resonance imaging contrast agents gained approval by US Food and Drug Administration (FDA). However, latter body of evidence revealed the overlooked side effects of IONPs, resulting in their withdrawal. Emerging evidence suggests that this happened due to poor understanding of the mechanisms by which IONPs act at the cellular and sub-cellular levels. Recent studies indicate that better understanding of fundamental signal modulations induced by nanomaterials is essential to overcome the clinical problems with nanoparticles. Therefore, in this article we critically review potential mechanisms of IONPs-cell interactions and challenges related with their identification.
    PracovištěFyzikální ústav
    KontaktKristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
    Rok sběru2021
    Elektronická adresahttps://doi.org/10.1016/j.jconrel.2020.08.036
Počet záznamů: 1