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The Role of Dietary Phenolic Compounds in Epigenetic Modulation Involved in Inflammatory Processes

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    SYSNO ASEP0537343
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevThe Role of Dietary Phenolic Compounds in Epigenetic Modulation Involved in Inflammatory Processes
    Tvůrce(i) Číž, Milan (BFU-R) RID, ORCID
    Dvořáková, Adéla (BFU-R)
    Skočková, Veronika (BFU-R)
    Kubala, Lukáš (BFU-R) RID, ORCID
    Celkový počet autorů4
    Číslo článku691
    Zdroj.dok.Antioxidants. - : MDPI
    Roč. 9, č. 8 (2020)
    Poč.str.19 s.
    Forma vydáníOnline - E
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovaproinflammatory cytokine production ; immune function ; dna methylation ; histone h3 ; in-vitro ; polyphenols ; resveratrol
    Vědní obor RIVCE - Biochemie
    Obor OECDBiochemistry and molecular biology
    Způsob publikováníOpen access
    Institucionální podporaBFU-R - RVO:68081707
    UT WOS000567166800001
    EID SCOPUS85090629678
    DOI10.3390/antiox9080691
    AnotaceA better understanding of the interactions between dietary phenolic compounds and the epigenetics of inflammation may impact pathological conditions and their treatment. Phenolic compounds are well-known for their antioxidant, anti-inflammatory, anti-angiogenic, and anti-cancer properties, with potential benefits in the treatment of various human diseases. Emerging studies bring evidence that nutrition may play an essential role in immune system modulation also by altering gene expression. This review discusses epigenetic mechanisms such as DNA methylation, post-translational histone modification, and non-coding microRNA activity that regulate the gene expression of molecules involved in inflammatory processes. Special attention is paid to the molecular basis of NF-kappa B modulation by dietary phenolic compounds. The regulation of histone acetyltransferase and histone deacetylase activity, which all influence NF-kappa B signaling, seems to be a crucial mechanism of the epigenetic control of inflammation by phenolic compounds. Moreover, chronic inflammatory processes are reported to be closely connected to the major stages of carcinogenesis and other non-communicable diseases. Therefore, dietary phenolic compounds-targeted epigenetics is becoming an attractive approach for disease prevention and intervention.
    PracovištěBiofyzikální ústav
    KontaktJana Poláková, polakova@ibp.cz, Tel.: 541 517 244
    Rok sběru2021
    Elektronická adresahttps://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=AdvancedSearch&qid=6&SID=F1xluL7bYBwwklPNBfn&page=1&doc=1
Počet záznamů: 1