Počet záznamů: 1
The Role of Dietary Phenolic Compounds in Epigenetic Modulation Involved in Inflammatory Processes
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SYSNO ASEP 0537343 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The Role of Dietary Phenolic Compounds in Epigenetic Modulation Involved in Inflammatory Processes Tvůrce(i) Číž, Milan (BFU-R) RID, ORCID
Dvořáková, Adéla (BFU-R)
Skočková, Veronika (BFU-R)
Kubala, Lukáš (BFU-R) RID, ORCIDCelkový počet autorů 4 Číslo článku 691 Zdroj.dok. Antioxidants. - : MDPI
Roč. 9, č. 8 (2020)Poč.str. 19 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova proinflammatory cytokine production ; immune function ; dna methylation ; histone h3 ; in-vitro ; polyphenols ; resveratrol Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology Způsob publikování Open access Institucionální podpora BFU-R - RVO:68081707 UT WOS 000567166800001 EID SCOPUS 85090629678 DOI 10.3390/antiox9080691 Anotace A better understanding of the interactions between dietary phenolic compounds and the epigenetics of inflammation may impact pathological conditions and their treatment. Phenolic compounds are well-known for their antioxidant, anti-inflammatory, anti-angiogenic, and anti-cancer properties, with potential benefits in the treatment of various human diseases. Emerging studies bring evidence that nutrition may play an essential role in immune system modulation also by altering gene expression. This review discusses epigenetic mechanisms such as DNA methylation, post-translational histone modification, and non-coding microRNA activity that regulate the gene expression of molecules involved in inflammatory processes. Special attention is paid to the molecular basis of NF-kappa B modulation by dietary phenolic compounds. The regulation of histone acetyltransferase and histone deacetylase activity, which all influence NF-kappa B signaling, seems to be a crucial mechanism of the epigenetic control of inflammation by phenolic compounds. Moreover, chronic inflammatory processes are reported to be closely connected to the major stages of carcinogenesis and other non-communicable diseases. Therefore, dietary phenolic compounds-targeted epigenetics is becoming an attractive approach for disease prevention and intervention. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2021 Elektronická adresa https://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=AdvancedSearch&qid=6&SID=F1xluL7bYBwwklPNBfn&page=1&doc=1
Počet záznamů: 1