Počet záznamů: 1
Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep
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SYSNO ASEP 0536633 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep Tvůrce(i) Šanda, Pavel (UIVT-O) SAI, RID
Malerba, P. (US)
Jiang, X. (US)
Krishnan, G. P. (US)
Gonzales-Martinez, J. (US)
Halgren, E. (US)
Bazhenov, M. (US)Celkový počet autorů 8 Zdroj.dok. Cerebral Cortex. - : Oxford University Press - ISSN 1047-3211
Roč. 31, č. 1 (2021), s. 324-340Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova network model ; NREM sleep ; sharp wave-ripple ; slow oscillation Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology Způsob publikování Omezený přístup Institucionální podpora UIVT-O - RVO:67985807 UT WOS 000608401000024 EID SCOPUS 85094167398 DOI 10.1093/cercor/bhaa228 Anotace The dialogue between cortex and hippocampus is known to be crucial for sleep-dependent memory consolidation. During slow wave sleep, memory replay depends on slow oscillation (SO) and spindles in the (neo)cortex and sharp wave-ripples (SWRs) in the hippocampus. The mechanisms underlying interaction of these rhythms are poorly understood. We examined the interaction between cortical SO and hippocampal SWRs in a model of the hippocampo–cortico–thalamic network and compared the results with human intracranial recordings during sleep. We observed that ripple occurrence peaked following the onset of an Up-state of SO and that cortical input to hippocampus was crucial to maintain this relationship. A small fraction of ripples occurred during the Down-state and controlled initiation of the next Up-state. We observed that the effect of ripple depends on its precise timing, which supports the idea that ripples occurring at different phases of SO might serve different functions, particularly in the context of encoding the new and reactivation of the old memories during memory consolidation. The study revealed complex bidirectional interaction of SWRs and SO in which early hippocampal ripples influence transitions to Up-state, while cortical Up-states control occurrence of the later ripples, which in turn influence transition to Down-state. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2022 Elektronická adresa http://dx.doi.org/10.1093/cercor/bhaa228
Počet záznamů: 1