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Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats
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SYSNO ASEP 0535840 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats Tvůrce(i) Mareš, Pavel (FGU-C) RID, ORCID
Kudová, Eva (UOCHB-X) RID, ORCID
Valeš, Karel (FGU-C) RID, ORCID, SAI
Kubová, Hana (FGU-C) RID, ORCIDZdroj.dok. Pharmacological Reports. - : Springer - ISSN 1734-1140
Roč. 72, č. 6 (2020), s. 1573-1578Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. PL - Polsko Klíč. slova cortical afterdischarges ; postical potentiation ; immature rats ; neurosteroids ; gabaergic drugs Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology Vědní obor RIV – spolupráce Ústav organické chemie a biochemie - Neurologie, neurochirurgie, neurovědy CEP GA18-09296S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 ; UOCHB-X - RVO:61388963 UT WOS 000539580800001 EID SCOPUS 85086101460 DOI 10.1007/s43440-020-00113-2 Anotace Background:Postictal potentiation presented immediately after cortical seizures in immature rats might be due to imbalance between excitation and inhibition. The aim of the present study was to determine whether augmentation of inhibition mediated by GABAA receptors could also suppress the postictal potentiation.Methods:Twelve-day old rats with implanted electrodes were used in our study. Five drugs were tested: the agonist muscimol, the positive modulator midazolam and three neurosteroids affecting GABAA receptors—allopregnanolone, pregnanolone sulphate and pregnanolone glutamate.Results:None of the five drugs was able to suppress potentiation appearing immediately after cortical epileptic afterdischarges, but all of them exhibited delayed anticonvulsant action 10 (in the case of midazolam and muscimol) or 20 min (all three steroids) after cortical seizures.Conclusion:Our results support a role of GABA in augmentation of cortical after discharges after longer intervals, whereas immediate postictal potentiation is not affected by GABAergic drugs. Due to similar effect with GABAergic drugs, the main mechanism of action of the three steroids tested is potentiation of GABAergic inhibition. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2021 Elektronická adresa https://doi.org/10.1007/s43440-020-00113-2
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