Počet záznamů: 1
Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer
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SYSNO ASEP 0534443 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer Tvůrce(i) Babuka, David (UMCH-V)
Kolouchová, Kristýna (UMCH-V) ORCID, RID
Groborz, Ondřej (UMCH-V) ORCID, RID
Tosner, Z. (CZ)
Zhigunov, Alexander (UMCH-V) RID, ORCID
Štěpánek, Petr (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCIDČíslo článku 2231 Zdroj.dok. Nanomaterials. - : MDPI
Roč. 10, č. 11 (2020), s. 1-17Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova fluorine-19 ; magnetic resonance imaging ; self-assembly Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP LTC19032 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA19-01602S GA ČR - Grantová agentura ČR GA18-07983S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000594374500001 EID SCOPUS 85095877392 DOI 10.3390/nano10112231 Anotace Fluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2021 Elektronická adresa https://www.mdpi.com/2079-4991/10/11/2231
Počet záznamů: 1