Počet záznamů: 1  

Internal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer

  1. 1.
    SYSNO ASEP0534443
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevInternal structure of thermoresponsive physically crosslinked nanogel of poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide], prominent 19F MRI tracer
    Tvůrce(i) Babuka, David (UMCH-V)
    Kolouchová, Kristýna (UMCH-V) ORCID, RID
    Groborz, Ondřej (UMCH-V) ORCID, RID
    Tosner, Z. (CZ)
    Zhigunov, Alexander (UMCH-V) RID, ORCID
    Štěpánek, Petr (UMCH-V) RID, ORCID
    Hrubý, Martin (UMCH-V) RID, ORCID
    Číslo článku2231
    Zdroj.dok.Nanomaterials
    Roč. 10, č. 11 (2020), s. 1-17
    Poč.str.17 s.
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovafluorine-19 ; magnetic resonance imaging ; self-assembly
    Vědní obor RIVCD - Makromolekulární chemie
    Obor OECDPolymer science
    CEPLTC19032 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    GA19-01602S GA ČR - Grantová agentura ČR
    GA18-07983S GA ČR - Grantová agentura ČR
    Způsob publikováníOpen access
    Institucionální podporaUMCH-V - RVO:61389013
    UT WOS000594374500001
    EID SCOPUS85095877392
    DOI10.3390/nano10112231
    AnotaceFluorine-19 MRI is a promising noninvasive diagnostic method. However, the absence of a nontoxic fluorine-19 MRI tracer that does not suffer from poor biodistribution as a result of its strong fluorophilicity is a constant hurdle in the widespread applicability of this otherwise versatile diagnostic technique. The poly[N-(2-hydroxypropyl)methacrylamide]-block-poly[N-(2,2-difluoroethyl)acrylamide] thermoresponsive copolymer was proposed as an alternative fluorine-19 MRI tracer capable of overcoming such shortcomings. In this paper, the internal structure of self-assembled particles of this copolymer was investigated by various methods including 1D and 2D NMR, dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The elucidated structure appears to be that of a nanogel with greatly swollen hydrophilic chains and tightly packed thermoresponsive chains forming a network within the nanogel particles, which become more hydrophobic with increasing temperature. Its capacity to provide a measurable fluorine-19 NMR signal in its aggregated state at human body temperature was also investigated and confirmed. This capacity stems from the different fluorine-19 nuclei relaxation properties compared to those of hydrogen-1 nuclei.
    PracovištěÚstav makromolekulární chemie
    KontaktEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Rok sběru2021
    Elektronická adresahttps://www.mdpi.com/2079-4991/10/11/2231
Počet záznamů: 1