Počet záznamů: 1  

Analysis of bile acids in human biological samples by microcolumn separation techniques: A review

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    SYSNO ASEP0531799
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAnalysis of bile acids in human biological samples by microcolumn separation techniques: A review
    Tvůrce(i) Dosedělová, V. (CZ)
    Itterheimová, P. (CZ)
    Kubáň, Petr (UIACH-O) ORCID
    Celkový počet autorů3
    Zdroj.dok.Electrophoresis - ISSN 0173-0835
    Roč. 42, 1-2 (2021), s. 68-85
    Poč.str.18 s.
    Forma vydáníTištěná - P
    Jazyk dok.eng - angličtina
    Země vyd.DE - Německo
    Klíč. slovatandem mass-spectrometry ; quantitative-analysis ; human plasma ; human urine ; clinical analysis ; gc-ms ; hplc-ms ; Microcolumn separation
    Vědní obor RIVCB - Analytická chemie, separace
    Obor OECDAnalytical chemistry
    Způsob publikováníOmezený přístup
    Institucionální podporaUIACH-O - RVO:68081715
    UT WOS000552288300001
    EID SCOPUS85088459043
    AnotaceBile acids are a group of compounds essential for lipid digestion and absorption with a steroid skeleton and a carboxylate side chain usually conjugated to glycine or taurine. Bile acids are regulatory molecules for a number of metabolic processes and can be used as biomarkers of various disorders. Since the middle of the twentieth century, the detection of bile acids has evolved from simple qualitative analysis to accurate quantification in complicated mixtures. Advanced methods are required to characterize and quantify individual bile acids in these mixtures. This article overviews the literature from the last two decades (2000-2020) and focuses on bile acid analysis in various human biological samples. The methods for sample preparation, including the sample treatment of conventional (blood plasma, blood serum, and urine) and unconventional samples (bile, saliva, duodenal/gastric juice, feces, etc.) are shortly discussed. Eventually, the focus is on novel analytical approaches and methods for each particular biological sample, providing an overview of the microcolumn separation techniques, such as high-performance liquid chromatography, gas chromatography, and capillary electrophoresis, used in their analysis. This is followed by a discussion on selected clinical applications.
    PracovištěÚstav analytické chemie
    KontaktIveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234
    Rok sběru2022
    Elektronická adresahttp://hdl.handle.net/11104/0310414
Počet záznamů: 1