Počet záznamů: 1  

Catalytic and redox activity of nucleic acids at mercury electrodes: Roles of nucleobase residues

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    SYSNO ASEP0524254
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevCatalytic and redox activity of nucleic acids at mercury electrodes: Roles of nucleobase residues
    Tvůrce(i) Římánková, Ludmila (BFU-R)
    Hasoň, Stanislav (BFU-R) RID, ORCID
    Daňhel, Aleš (BFU-R) RID, ORCID
    Fojta, Miroslav (BFU-R) RID, ORCID
    Ostatná, Veronika (BFU-R) RID, ORCID
    Celkový počet autorů5
    Číslo článku113812
    Zdroj.dok.Journal of Electroanalytical Chemistry - ISSN 1572-6657
    Roč. 858, FEB 1 2020 (2020)
    Poč.str.6 s.
    Forma vydáníOnline - E
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovahydrogen evolution ; dna ; electrochemistry ; oligonucleotides
    Vědní obor RIVCB - Analytická chemie, separace
    Obor OECDElectrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
    CEPGA17-08971S GA ČR - Grantová agentura ČR
    EF15_003/0000477 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    Způsob publikováníOmezený přístup
    Institucionální podporaBFU-R - RVO:68081707
    UT WOS000515205600043
    EID SCOPUS85077739525
    DOI10.1016/j.jelechem.2019.113812
    AnotaceUsing a series of specifically designed oligonucleotides we have identified adenine and cytosine nucleobases as residues involved in catalytic hydrogen evolution reaction (CHER) of nucleic acids at the hanging mercury drop electrode (HMDE). Due to the CHER, nucleic acids yield catalytic peak H-NA allowing their label-free and reagent-less analysis at low concentrations. Additionally, our results suggest that presence of the electroactive bases (adenine and cytosine) facilitates guanine reduction which is for the first time linked to a signal measurable at the HMDE the peak P. We assume that the peak P is connected with reduction of guanine to 7,8-dihydroguanine, of which reoxidation to guanine is detected at the electrode by the earlier described anodic peak G. Processes connected with the above mentioned signals were studied using cyclic voltammetry by inspection of dependences on experimental parameters such as negative vertex potential and pH. (C) 2019 Elsevier B.V. All rights reserved.
    PracovištěBiofyzikální ústav
    KontaktJana Poláková, polakova@ibp.cz, Tel.: 541 517 244
    Rok sběru2021
    Elektronická adresahttps://www.sciencedirect.com/science/article/pii/S157266571931080X?via%3Dihub
Počet záznamů: 1