Počet záznamů: 1  

The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy

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    SYSNO ASEP0521636
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevThe Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy
    Tvůrce(i) Plzák, J. (CZ)
    Bouček, J. (CZ)
    Bandurova, V. (CZ)
    Kolář, Michal (UMG-J) RID
    Hradilová, Miluše (UMG-J)
    Szabo, P. (CZ)
    Lacina, L. (CZ)
    Chovanec, M. (CZ)
    Smetana, K. (CZ)
    Celkový počet autorů9
    Číslo článku440
    Zdroj.dok.Cancers (Basel). - : MDPI
    Roč. 11, č. 4 (2019)
    Poč.str.19 s.
    Forma vydáníOnline - E
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovacancer ; cancer microenvironment ; cancer ecosystem ; cancer-associated fibroblast ; extracellular matrix ; cytokine ; il-6 ; tumour-associated macrophages ; cancer therapy
    Vědní obor RIVEB - Genetika a molekulární biologie
    Obor OECDBiochemistry and molecular biology
    CEPLQ1604 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    ED1.1.00/02.0109 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    Způsob publikováníOpen access
    Institucionální podporaUMG-J - RVO:68378050
    UT WOS000467773400008
    DOI10.3390/cancers11040440
    AnotaceSimilarly to other types of malignant tumours, the incidence of head and neck cancer is increasing globally. It is frequently associated with smoking and alcohol abuse, and in a broader sense also with prolonged exposure to these factors during ageing. A higher incidence of tumours observed in younger populations without a history of alcohol and tobacco abuse may be due to HPV infection. Malignant tumours form an intricate ecosystem of cancer cells, fibroblasts, blood/lymphatic capillaries and infiltrating immune cells. This dynamic system, the tumour microenvironment, has a significant impact on the biological properties of cancer cells. The microenvironment participates in the control of local aggressiveness of cancer cells, their growth, and their consequent migration to lymph nodes and distant organs during metastatic spread. In cancers originating from squamous epithelium, a similarity was demonstrated between the cancer microenvironment and healing wounds. In this review, we focus on the specificity of the microenvironment of head and neck cancer with emphasis on the mechanism of intercellular crosstalk manipulation for potential therapeutic application.
    PracovištěÚstav molekulární genetiky
    KontaktGabriela Marešová, maresova@img.cas.cz, Tel.: 241 063 217
    Rok sběru2020
    Elektronická adresahttps://www.mdpi.com/2072-6694/11/4/440
Počet záznamů: 1