Počet záznamů: 1
Interaction pathways and structure-chemical transformations of alginate gels in physiological environments
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SYSNO ASEP 0510805 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Interaction pathways and structure-chemical transformations of alginate gels in physiological environments Tvůrce(i) Urbanová, Martina (UMCH-V) RID, ORCID
Pavelková, M. (CZ)
Czernek, Jiří (UMCH-V) RID
Kubová, K. (CZ)
Vysloužil, J. (CZ)
Pechová, A. (CZ)
Molinková, D. (CZ)
Vysloužil, J. (CZ)
Vetchý, D. (CZ)
Brus, Jiří (UMCH-V) RID, ORCIDZdroj.dok. Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 20, č. 11 (2019), s. 4158-4170Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova alginate gels ; molecular-level interactions ; physiological conditions Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LTAUSA18011 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000496343800012 EID SCOPUS 85074441891 DOI 10.1021/acs.biomac.9b01052 Anotace The remarkably diverse affinity of alginate (ALG) macromolecules for polyvalent metal ions makes cross-linked alginate gels an outstanding biomaterial. Surprisingly, however, very little is known about their interactions and structural transformations in physiological environments. To bridge this gap, we prepared a set of ALG gels cross-linked by various ions and monitored their structural changes at different media simulating gastric and intestinal fluids and cellular environments. For these studies, we used multinuclear solid-state NMR (ss-NMR) spectroscopy, which revealed a range of competitive ion-exchange and interconversion reactions, the rate of which strongly depended on the nature of the cross-linking metal ions. Depending on the environment, ALG chains adopted different forms, such as acidic (hydro)gels stabilized by strong hydrogen bonds, and/or weakly cross-linked Na/H-gels. Simultaneously, the exchanged polyvalent ions extensively interacted with the environment even forming in some cases insoluble phosphate microdomains directly deposited in the ALG bead matrix. The extent of the transformations and incorporation of secondary phases into the alginate beads followed the size and electronegativity of the cross-linking ions. Overall, the applied combination of various macroscopic and biological tests with multinuclear ss-NMR revealed a complex pathway of alginate beads transformations in physiological environments. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2020 Elektronická adresa https://pubs.acs.org/doi/10.1021/acs.biomac.9b01052
Počet záznamů: 1