Počet záznamů: 1
Recent achievements in medicinal and supramolecular chemistry of betulinic acid and its derivatives
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SYSNO ASEP 0509279 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Recent achievements in medicinal and supramolecular chemistry of betulinic acid and its derivatives Tvůrce(i) Bildziukevich, Uladzimir (UEB-Q) RID, ORCID
Özdemir, Zülal (UEB-Q) ORCID
Wimmer, Zdeněk (UEB-Q) RID, ORCIDCelkový počet autorů 3 Číslo článku 3546 Zdroj.dok. Molecules. - : MDPI
Roč. 24, č. 19 (2019)Poč.str. 20 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova ADME parameters ; Antitumor activity ; Antiviral activity ; Betulinic acid ; Cytotoxicity ; Physicochemical parameters ; Structural modification ; Supramolecular self-assembly Vědní obor RIV CC - Organická chemie Obor OECD Chemical engineering (plants, products) CEP FV10599 GA MPO - Ministerstvo průmyslu a obchodu FV30300 GA MPO - Ministerstvo průmyslu a obchodu Způsob publikování Open access Institucionální podpora UEB-Q - RVO:61389030 UT WOS 000496242300131 EID SCOPUS 85072762176 DOI 10.3390/molecules24193546 Anotace The subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse derivatives, with special focus on their cytotoxic effect, antitumor activity, and antiviral effect, and mostly covers a period 2015–2018. Literature sources published earlier are referred to in required coherences or from historical points of view. Relationships between pharmacological activity and supramolecular characteristics are included if such investigation has been done in the original literature sources. A wide practical applicability of betulinic acid and its derivatives demonstrated in the literature sources is also included in this review article. Several literature sources also focused on in silico calculation of physicochemical and ADME parameters of the developed compounds, and on a comparison between the experimental and calculated data. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2020 Elektronická adresa http://dx.doi.org/10.3390/molecules24193546
Počet záznamů: 1