Počet záznamů: 1

Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport

SYSNO ASEP	0504410
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport
Tvůrce(i)	Horáková, Olga (FGU-C)_{RID, ORCID} Kroupová, Petra (FGU-C)_ORCID Bardová, Kristina (FGU-C)_{RID, ORCID, SAI} Burešová, Jana (FGU-C)_{ORCID, RID} Janovská, Petra (FGU-C)_{RID, ORCID} Kopecký, Jan (FGU-C)_{RID, ORCID} Rossmeisl, Martin (FGU-C)_{RID, ORCID}
Číslo článku	6156
Zdroj.dok.	Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322 Roč. 9, Apr 16 (2019)
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	metformin ; blood glucose ; small intestine ; glucose transport ; mice ; AMP-activated protein kinase
Vědní obor RIV	FB - Endokrinologie, diabetologie, metabolizmus, výživa
Obor OECD	Endocrinology and metabolism (including diabetes, hormones)
CEP	GA16-08124S GA ČR - Grantová agentura ČR
Způsob publikování	Open access
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000464652400027
EID SCOPUS	85064569500
DOI	10.1038/s41598-019-42531-0
Anotace	Metformin is currently the most prescribed drug for treatment of type 2 diabetes mellitus in humans. It has been well established that long-term treatment with metformin improves glucose tolerance in mice by inhibiting hepatic gluconeogenesis. Interestingly, a single dose of orally administered metformin acutely lowers blood glucose levels, however, little is known about the mechanism involved in this effect. Glucose tolerance, as assessed by the glucose tolerance test, was improved in response to prior oral metformin administration when compared to vehicle-treated mice, irrespective of whether the animals were fed either the standard or high-fat diet. Blood glucose-lowering effects of acutely administered metformin were also observed in mice lacking functional AMP-activated protein kinase, and were independent of g lucagon-like-peptide-1 or N-methyl-D-aspartate receptors signaling. [F-18]-FDG/PET revealed a slower intestinal transit of labeled glucose after metformin as compared to vehicle administration. Finally, metformin in a dose-dependent but indirect manner decreased glucose transport from the intestinal lumen into the blood, which was observed ex vivo as well as in vivo. Our results support the view that the inhibition of transepithelial glucose transport in the intestine is responsible for lowering blood glucose levels during an early response to oral administration of metformin.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2020
Elektronická adresa	https://doi.org/10.1038/s41598-019-42531-0

Počet záznamů: 1