Počet záznamů: 1
Muscle Cell and Tissue : Current Status of Research Field
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SYSNO ASEP 0499717 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Vascular Smooth Muscle Cells (VSMCs) in Blood Vessel Tissue Engineering: The Use of Differentiated Cells or Stem Cells as VSMC Precursors Tvůrce(i) Bačáková, Lucie (FGU-C) RID, ORCID
Trávníčková, Martina (FGU-C) RID, ORCID, SAI
Filová, Elena (FGU-C) RID, ORCID
Matějka, Roman (FGU-C) RID, ORCID, SAI
Štěpanovská, Jana (FGU-C) ORCID, RID
Musílková, Jana (FGU-C) RID, ORCID
Zárubová, Jana (FGU-C) RID, ORCID
Molitor, M. (CZ)Zdroj.dok. Muscle Cell and Tissue : Current Status of Research Field. - London : IntechOpen, 2018 / Sakuma Kunihiro - ISBN 978-1-78984-006-3 Rozsah stran s. 289-308 Poč.str. 20 s. Poč.str.knihy 357 Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova vascular replacement ; adipose tissue-derived stem cells ; transforming growth factor-beta ; bone morphogenetic protein-4 ; mechanical loading ; dynamic bioreactors ; smooth muscle cell differentiation ; tissue engineering ; regenerative medicine Vědní obor RIV EI - Biotechnologie a bionika Obor OECD Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction) CEP NV15-33018A GA MZd - Ministerstvo zdravotnictví LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2015062 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora FGU-C - RVO:67985823 DOI 10.5772/intechopen.77108 Anotace Vascular smooth muscle cells (VSMCs) play important roles in the physiology and pathophysiology of the blood vessels. In a healthy adult organism, VSMCs are quiescent, but after a blood vessel injury, they undergo phenotypic modulation from the contractile phenotype to the synthetic phenotype, characterized by high activity in migration, proliferation and proteosynthesis. This behavior of VSMCs can lead to stenosis or obliteration of the vascular lumen. For this reason, VSMCs have tended to be avoided in the construction of blood vessel replacements. However, VSMCs are a physiological and the most numerous component of blood vessels, so their presence in novel advanced vascular replacements is indispensable. Either differentiated VSMCs or stem cells as precursors of VSMCs can be used in the reconstruction of the tunica media in these replacements. VSMCs can be obtained from blood vessels (usually from subcutaneous veins) taken surgically from the patients and can be expanded in vitro. During in vitro cultivation, VSMCs lose their differentiation markers, at least partly. These cells should therefore be re-differentiated by seeding them on appropriate scaffolds by composing cell culture media and by mechanical stimulation in dynamic bioreactors. Similar approaches can also be applied for differentiating stem cells, particularly adipose tissue-derived stem cells, toward VSMCs for the purposes of vascular tissue engineering. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2019
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