Počet záznamů: 1

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

SYSNO ASEP	0498725
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
Tvůrce(i)	Chang, W.C. (GB) Kudláček, Jan (FGU-C)_ORCID Hlinka, Jaroslav (UIVT-O)_{RID, SAI, ORCID} Chvojka, Jan (FGU-C)_ORCID Hadrava, Michal (UIVT-O)_{RID, ORCID, SAI} Kumpošt, Vojtěch (FGU-C)_ORCID Powell, A. D. (GB) Janča, R. (CZ) Maturana, M. I. (AU) Karoly, P. J. (AU) Freestone, D. R. (AU) Cook, M. J. (AU) Paluš, Milan (UIVT-O)_{RID, SAI, ORCID} Otáhal, Jakub (FGU-C)_{RID, ORCID, SAI} Jefferys, J. G. R. (GB) Jiruška, Přemysl (FGU-C)_{RID, ORCID, SAI}
Zdroj.dok.	Nature Neuroscience. - : Nature Publishing Group - ISSN 1097-6256 Roč. 21, č. 12 (2018), s. 1742-1752
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	seizures ; dynamics ; perturbations ; transition to seizure ; critical slowing ; catastrophic shifts ; high-frequency activity ; interictal epileptiform discharges
Vědní obor RIV	FH - Neurologie, neurochirurgie, neurovědy
Obor OECD	Neurosciences (including psychophysiology
CEP	GA14-02634S GA ČR - Grantová agentura ČR
	NV15-29835A GA MZd - Ministerstvo zdravotnictví
	NV17-28427A GA MZd - Ministerstvo zdravotnictví
Institucionální podpora	FGU-C - RVO:67985823 ; UIVT-O - RVO:67985807
UT WOS	000451324700012
EID SCOPUS	85057290648
DOI	10.1038/s41593-018-0278-y
Anotace	The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2019

Počet záznamů: 1