Počet záznamů: 1  

beta-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxia

  1. 1.
    SYSNO ASEP0490865
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    Názevbeta-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxia
    Tvůrce(i) Hahnová, K. (CZ)
    Brabcová, I. (CZ)
    Neckář, Jan (FGU-C) RID, ORCID
    Weissová, Romana (FGU-C) ORCID, RID, SAI
    Svatoňová, Anna (FGU-C)
    Nováková, O. (CZ)
    Žurmanová, J. (CZ)
    Kalous, M. (CZ)
    Šilhavý, Jan (FGU-C) RID, ORCID
    Pravenec, Michal (FGU-C) RID, ORCID
    Kolář, František (FGU-C) RID, ORCID, SAI
    Novotný, J. (CZ)
    Zdroj.dok.Journal of Physiological Sciences. - : BioMed Central - ISSN 1880-6546
    Roč. 68, č. 4 (2018), s. 441-454
    Poč.str.14 s.
    Jazyk dok.eng - angličtina
    Země vyd.JP - Japonsko
    Klíč. slovaSHR ; mitochondrial genome ; myocardium ; beta-adrenergic receptors ; adenylyl cyclase ; monoamine oxidase A ; antioxidant defence ; chronic hypoxia
    Vědní obor RIVED - Fyziologie
    Obor OECDPhysiology (including cytology)
    CEPGA13-10267S GA ČR - Grantová agentura ČR
    LL1204 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    GAP301/12/0696 GA ČR - Grantová agentura ČR
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000434180700012
    EID SCOPUS85020060772
    DOI10.1007/s12576-017-0546-8
    AnotaceThe beta-adrenergic signaling pathways and antioxidant defence mechanisms play important roles in maintaining proper heart function. Here, we examined the effect of chronic normobaric hypoxia (CNH, 10% O-2, 3 weeks) on myocardial beta-adrenergic signaling and selected components of the antioxidant system in spontaneously hypertensive rats (SHR) and in a conplastic SHR-mtBN strain characterized by the selective replacement of the mitochondrial genome of SHR with that of the more ischemia-resistant Brown Norway strain. Our investigations revealed some intriguing differences between the two strains at the level of beta-adrenergic receptors (beta-ARs), activity of adenylyl cyclase (AC) and monoamine oxidase A (MAO-A), as well as distinct changes after CNH exposure. The beta(2)-AR/beta(1)-AR ratio was significantly higher in SHR-mtBN than in SHR, apparently due to increased expression of beta(2)-ARs. Adaptation to hypoxia elevated beta(2)-ARs in SHR and decreased the total number of beta-ARs in SHR-mtBN. In parallel, the ability of isoprenaline to stimulate AC activity was found to be higher in SHR-mtBN than that in SHR. Interestingly, the activity of MAO-A was notably lower in SHR-mtBN than in SHR, and it was markedly elevated in both strains after exposure to hypoxia. In addition to that, CNH markedly enhanced the expression of catalase and aldehyde dehydrogenase-2 in both strains, and decreased the expression of Cu/Zn superoxide dismutase in SHR. Adaptation to CNH intensified oxidative stress to a similar extent in both strains and elevated the IL-10/TNF-alpha ratio in SHR-mtBN only. These data indicate that alterations in the mitochondrial genome can result in peculiar changes in myocardial beta-adrenergic signaling, MAO-A activity and antioxidant defence and may, thus, affect the adaptive responses to hypoxia.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2019
Počet záznamů: 1  

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