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Arbidol (Umifenovir): A broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses

SYSNO ASEP	0489098
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Arbidol (Umifenovir): A broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses
Tvůrce(i)	Haviernik, J. (CZ) Štefánik, M. (CZ) Fojtíková, M. (CZ) Kali, S. (FR) Tordo, N. (FR) Rudolf, Ivo (UBO-W)_{RID, ORCID, SAI} Hubálek, Zdeněk (UBO-W)_{RID, SAI, ORCID} Eyer, Luděk (BC-A)_{RID, ORCID} Růžek, Daniel (BC-A)_{RID, ORCID}
Celkový počet autorů	9
Číslo článku	184
Zdroj.dok.	Viruses. - : MDPI Roč. 10, č. 4 (2018)
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	CH - Švýcarsko
Klíč. slova	Antiviral activity ; Arbidol ; Cell-type dependent antiviral effect ; Cytotoxicity ; Flavivirus ; Umifenovir
Vědní obor RIV	EE - Mikrobiologie, virologie
Obor OECD	Virology
Vědní obor RIV – spolupráce	Biologické centrum (od r. 2006) - Mikrobiologie, virologie
CEP	GA16-20054S GA ČR - Grantová agentura ČR
Způsob publikování	Open access
Institucionální podpora	UBO-W - RVO:68081766 ; BC-A - RVO:60077344
UT WOS	000435184400045
EID SCOPUS	85045314142
DOI	10.3390/v10040184
Anotace	Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compound shows activities against numerous DNA and RNA viruses. The mode of action is based predominantly on impairment of critical steps in virus-cell interactions. Here we demonstrate that arbidol possesses micromolar-level anti-viral effects (EC 50 values ranging from 10.57 ± 0.74 to 19.16 ± 0.29 µM) in Vero cells infected with Zika virus, West Nile virus, and tick-borne encephalitis virus, three medically important representatives of the arthropod-borne flaviviruses. Interestingly, no antiviral effects of arbidol are observed in virus infected porcine stable kidney cells (PS), human neuroblastoma cells (UKF-NB-4), and human hepatoma cells (Huh-7 cells) indicating that the antiviral effect of arbidol is strongly cell-type dependent. Arbidol shows increasing cytotoxicity when tested in various cell lines, in the order: Huh-7 < HBCA < PS < UKF-NB-4 < Vero with CC 50 values ranging from 18.69 ± 0.1 to 89.72 ± 0.19 µM. Antiviral activities and acceptable cytotoxicity profiles suggest that arbidol could be a promising candidate for further investigation as a potential therapeutic agent in selective treatment of flaviviral infections.
Pracoviště	Ústav biologie obratlovců
Kontakt	Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
Rok sběru	2019
Elektronická adresa	https://www.mdpi.com/1999-4915/10/4/184/pdf

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