Počet záznamů: 1
Clearing the outer mitochondrial membrane from harmful proteins via lipid droplets
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SYSNO ASEP 0484574 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Clearing the outer mitochondrial membrane from harmful proteins via lipid droplets Tvůrce(i) Bischof, J. (AT)
Salzmann, M. (AT)
Streubel, M.K. (AT)
Hašek, Jiří (MBU-M) RID, ORCID
Geltinger, F. (AT)
Duschl, J. (AT)
Bresgen, N. (AT)
Briza, P. (AT)
Hašková, Danuša (MBU-M)
Lejsková, Renata (MBU-M) RID
Sopjani, M. (XK)
Richter, K. (AT)
Rinnerthaler, M. (AT)Číslo článku 17016 Zdroj.dok. Cell Death Discovery
Roč. 3, March 20 (2017)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova mitochondrial membrane ; harmful proteins ; lipid droplets Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP GA16-05497S GA ČR - Grantová agentura ČR 7AMB16AT006 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora MBU-M - RVO:61388971 UT WOS 000463082900029 DOI 10.1038/cddiscovery.2017.16 Anotace In recent years it turned out that there is not only extensive communication between the nucleus and mitochondria but also between mitochondria and lipid droplets (LDs) as well. We were able to demonstrate that a number of proteins shuttle between LDs and mitochondria and it depends on the metabolic state of the cell on which organelle these proteins are predominantly localized. Responsible for the localization of the particular proteins is a protein domain consisting of two alfa-helices, which we termed V-domain according to the predicted structure. So far we have detected this domain in the following proteins: mammalian BAX, BCL-XL, TCTP and yeast Mmi1p and Erg6p. According to our experiments there are two functions of this domain: (1) shuttling of proteins to mitochondria in times of stress and apoptosis, (2) clearing the outer mitochondrial membrane from pro- as well as anti-apoptotic proteins by moving them to LDs after the stress ceases. In this way the LDs are used by the cell to modulate stress response. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2018
Počet záznamů: 1