Počet záznamů: 1  

A DNA Structural Alphabet Distinguishes Structural Features of DNA Bound to Regulatory Proteins and in the Nucleosome Core Particle

  1. 1.
    SYSNO ASEP0484505
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevA DNA Structural Alphabet Distinguishes Structural Features of DNA Bound to Regulatory Proteins and in the Nucleosome Core Particle
    Tvůrce(i) Schneider, Bohdan (BTO-N) RID, ORCID
    Božíková, Paulina (BTO-N)
    Čech, P. (CZ)
    Svozil, D. (CZ)
    Černý, Jiří (BTO-N) RID, ORCID
    Celkový počet autorů5
    Číslo článku278
    Zdroj.dok.Genes. - : MDPI
    Roč. 8, č. 10 (2017)
    Poč.str.15 s.
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovaDNA ; DNA-protein recognition ; transcription factors
    Vědní obor RIVEB - Genetika a molekulární biologie
    Obor OECDComputer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
    CEPED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    Institucionální podporaBTO-N - RVO:86652036
    UT WOS000414862300043
    EID SCOPUS85032005464
    DOI10.3390/genes8100278
    AnotaceWe analyzed the structural behavior of DNA complexed with regulatory proteins and the nucleosome core particle (NCP). The three-dimensional structures of almost 25 thousand dinucleotide steps from more than 500 sequentially non-redundant crystal structures were classified by using DNA structural alphabet CANA (Conformational Alphabet of Nucleic Acids) and associations between ten CANA letters and sixteen dinucleotide sequences were investigated. The associations showed features discriminating between specific and non-specific binding of DNA to proteins. Important is the specific role of two DNA structural forms, A-DNA, and BII-DNA, represented by the CANA letters AAA and BB2: AAA structures are avoided in non-specific NCP complexes, where the wrapping of the DNA duplex is explained by the periodic occurrence of BB2 every 10.3 steps. In both regulatory and NCP complexes, the extent of bending of the DNA local helical axis does not influence proportional representation of the CANA alphabet letters, namely the relative incidences of AAA and BB2 remain constant in bent and straight duplexes.
    PracovištěBiotechnologický ústav
    KontaktMonika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
    Rok sběru2018
Počet záznamů: 1  

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