Počet záznamů: 1
A Unique ISR Program Determines Cellular Responses to Chronic Stress
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SYSNO ASEP 0483711 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A Unique ISR Program Determines Cellular Responses to Chronic Stress Tvůrce(i) Guan, B.J. (US)
van Hoef, V. (SE)
Jobava, R. (US)
Elroy-Stein, O. (IL)
Valášek, Leoš Shivaya (MBU-M) RID, ORCID
Cargnello, M. (CA)
Gao, X.H. (US)
Krokowski, D. (US)
Merrick, W.C. (US)
Kimball, S.R. (US)
Komar, A.A. (US)
Koromilas, A.E. (CA)
Wynshaw-Boris, A. (US)
Topisirovic, I. (CA)
Larsson, O. (SE)
Hatzoglou, M. (US)Zdroj.dok. Molecular Cell. - : Cell Press - ISSN 1097-2765
Roč. 68, č. 5 (2017), s. 885-900Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova UNFOLDED PROTEIN RESPONSE ; EUKARYOTIC TRANSLATION INITIATION ; ENDOPLASMIC-RETICULUM STRESS Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP GA17-06238S GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000417646500009 EID SCOPUS 85037833477 DOI 10.1016/j.molcel.2017.11.007 Anotace The integrated stress response (ISR) is a homeostatic mechanisminduced by endoplasmic reticulum (ER) stress. In acute/transient ER stress, decreased global protein synthesis and increased uORF mRNA translation are followed by normalization of protein synthesis. Here, we report a dramatically different response during chronic ER stress. This chronic ISR program is characterized by persistently elevated uORF mRNA translation and concurrent gene expression reprogramming, which permits simultaneous stress sensing and proteostasis. The program includes PERK-dependent switching to an eIF3-dependent translation initiation mechanism, resulting in partial, but not complete, translational recovery, which, together with transcriptional reprogramming, selectively bolsters expression of proteins with ER functions. Coordination of transcriptional and translational reprogramming prevents ER dysfunction and inhibits 'foamy cell' development, thus establishing a molecular basis for understanding human diseases associated with ER dysfunction. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2018
Počet záznamů: 1