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Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon
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SYSNO ASEP 0483638 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon Tvůrce(i) Polidarová, Lenka (FGU-C) RID, ORCID
Houdek, Pavel (FGU-C) ORCID
Sumová, Alena (FGU-C) RID, ORCIDZdroj.dok. Chronobiology International - ISSN 0742-0528
Roč. 34, č. 9 (2017), s. 1273-1287Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova aging ; colon ; constant light ; melatonin ; proinflammatory cytokine ; Rgs16 ; sleep disruption Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GA14-07711S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000418361300011 EID SCOPUS 85031506158 DOI 10.1080/07420528.2017.1361436 Anotace Exposure to environmental conditions that disturb the daily rhythms has been shown to enhance the proinflammatory responses of immunostimulant-challenged immune system. However, it is not known whether circadian disturbances may stimulate unchallenged immune responses and thus contribute per se to the development of inflammation-related diseases. Our aim was to ascertain an effect of various conditions threatening the behavioral activity/rest cycle regulation, namely aging with or without melatonin, 6-h advance/delay phase shifts in the light/dark cycle repeated with a 2-day frequency and constant light, on expression of immune markers in the rat colon. We detected impact of these conditions on parameters of behavioral activity and mRNA levels of selected immune markers in the colonic mucosa of Wistar rats, namely TNFa (Tnf), IL1a (Il1a), IL17RA (Il17ra), STAT3 (Stat3), and Rgs16 (Rsg16), were detected. Exposure to constant light, which perturbed the interval of inactivity (sleep) and led to the complete abolishment of activity/inactivity cycles, activated robustly proinflammatory state in the colon selectively via Stat3-dependent pathway. These results provided the first evidence that disruptions in the behavioral activity/inactivity cycles may spontaneously (without immuno-stimulant) induce selective proinflammatory responses in the colonic mucosa. Such effects may take part in the mechanisms of modern lifestyle-induced inflammatory diseases of the gut. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2018
Počet záznamů: 1