Počet záznamů: 1
Strong antimicrobial activity of xanthohumol and other derivatives from hops (Humulus lupulus L.) on gut anaerobic bacteria
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SYSNO ASEP 0481502 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Strong antimicrobial activity of xanthohumol and other derivatives from hops (Humulus lupulus L.) on gut anaerobic bacteria Tvůrce(i) Čermák, P. (CZ)
Olšovská, J. (CZ)
Mikyška, A. (CZ)
Dušek, M. (CZ)
Kadlečková, Z. (CZ)
Vaníček, J. (CZ)
Nyč, O. (CZ)
Sigler, Karel (MBU-M) RID
Bostíková, V. (CZ)
Bostík, P. (CZ)Zdroj.dok. Acta Pathologica Microbiologica et Immunologica Scandinavica - ISSN 0903-4641
Roč. 125, č. 11 (2017), s. 1033-1038Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Xanthohumol ; gut ; anaerobic bacteria Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology Institucionální podpora MBU-M - RVO:61388971 UT WOS 000413915600010 EID SCOPUS 85030637871 DOI 10.1111/apm.12747 Anotace Anaerobic bacteria, such as Bacteroides fragilis or Clostridium perfringens, are part of indigenous human flora. However, Clostridium difficile represents also an important causative agent of nosocomial infectious antibiotic-associated diarrhoea. Treatment of C.difficile infection is problematic, making it imperative to search for new compounds with antimicrobial properties. Hops (Humulus lupulus L.) contain substances with antibacterial properties. We tested antimicrobial activity of purified hop constituents humulone, lupulone and xanthohumol against anaerobic bacteria. The antimicrobial activity was established against B.fragilis, C.perfringens and C.difficile strains according to standard testing protocols (CLSI, EUCAST), and the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBC) were calculated. All C.difficile strains were toxigenic and clinically relevant, as they were isolated from patients with diarrhoea. Strongest antimicrobial effects were observed with xanthohumol showing MIC and MBC values of 15-107g/mL, which are close to those of conventional antibiotics in the strains of bacteria with increased resistance. Slightly higher MIC and MBC values were obtained with lupulone followed by higher values of humulone. Our study, thus, shows a potential of purified hop compounds, especially xanthohumol, as alternatives for treatment of infections caused by select anaerobic bacteria, namely nosocomial diarrhoea caused by resistant strains. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2018
Počet záznamů: 1