Počet záznamů: 1  

Selective rab11 transport and the intrinsic regenerative ability of CNS axons

  1. 1.
    SYSNO ASEP0481164
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevSelective rab11 transport and the intrinsic regenerative ability of CNS axons
    Tvůrce(i) Koseki, H. (GB)
    Donegá, M. (GB)
    Lam, B.Y.H. (GB)
    Petrová, V. (GB)
    van Erp, S. (GB)
    Yeo, G.S.H. (GB)
    Kwok, Jessica (UEM-P) ORCID, RID
    Ffrench-Constant, Ch. (GB)
    Eva, R. (GB)
    Fawcett, James (UEM-P) ORCID
    Zdroj.dok.eLife. - : eLife - ISSN 2050-084X
    Roč. 6, aug (2017), e26956
    Poč.str.25 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaspinal-cord-injury ; chondroitin sulfate proteoglycans ; growth cone
    Vědní obor RIVFH - Neurologie, neurochirurgie, neurovědy
    Obor OECDNeurosciences (including psychophysiology
    CEPEF15_003/0000419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
    Institucionální podporaUEM-P - RVO:68378041
    UT WOS000411664100001
    EID SCOPUS85030710450
    DOI10.7554/eLife.26956
    AnotaceNeurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability of cut CNS axons to form a new growth cone and then elongate. Failure of regeneration was associated with increased retraction after axotomy. Transportation into axons becomes selective with maturation, we hypothesized that selective exclusion of molecules needed for growth may contribute to regeneration decline. With neuronal maturity rab11 vesicles (which carry many molecules involved in axon growth) became selectively targeted to the somatodendritic compartment and excluded from axons by predominant retrograde transport However, on overexpression rab11 was mistrafficked into proximal axons, and these axons showed less retraction and enhanced regeneration after axotomy. These results suggest that the decline of intrinsic axon regenerative ability is associated with selective exclusion of key molecules, and that manipulation of transport can enhance regeneration.
    PracovištěÚstav experimentální medicíny
    KontaktLenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
    Rok sběru2018
Počet záznamů: 1  

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