Počet záznamů: 1
Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts
- 1.
SYSNO ASEP 0478905 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts Tvůrce(i) Belli, A. (CH)
Sarr, A. (CH)
Rais, O. (CH)
Rego, Ryan O. M. (BC-A) RID, ORCID
Voordouw, M.J. (CH)Celkový počet autorů 5 Číslo článku 5006 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 7, JUL 10 (2017)Poč.str. 13 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Ixodes ricinus ticks ; disease spirochete ; borne pathogens ; r-0 model ; vector ; mice ; immunity ; persistence Vědní obor RIV GJ - Choroby a škůdci zvířat, veterinární medicína Obor OECD Veterinary science Institucionální podpora BC-A - RVO:60077344 UT WOS 000405180900079 EID SCOPUS 85022334031 DOI 10.1038/s41598-017-05231-1 Anotace Vector-borne pathogens establish systemic infections in host tissues to maximize transmission to arthropod vectors. Co-feeding transmission occurs when the pathogen is transferred between infected and naive vectors that feed in close spatiotemporal proximity on a host that has not yet developed a systemic infection. Borrelia afzelii is a tick-borne spirochete bacterium that causes Lyme borreliosis (LB) and is capable of co-feeding transmission. Whether ticks that acquire LB pathogens via co-feeding are actually infectious to vertebrate hosts has never been tested. We created nymphs that had been experimentally infected as larvae with B. afzelii via co-feeding or systemic transmission, and compared their performance over one complete LB life cycle. Co-feeding nymphs had a spirochete load that was 26 times lower than systemic nymphs but both nymphs were highly infectious to mice (i.e., probability of nymph-to-host transmission of B. afzelii was similar to 100%). The mode of transmission had no effect on the other infection phenotypes of the LB life cycle. Ticks that acquire B. afzelii via co-feeding transmission are highly infectious to rodents, and the resulting rodent infection is highly infectious to larval ticks. This is the first study to show that B. afzelii can use co-feeding transmission to complete its life cycle. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2018
Počet záznamů: 1