Počet záznamů: 1

Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models

SYSNO ASEP	0478611
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models
Tvůrce(i)	Kostiv, Uliana (UMCH-V)_RID Rajsiglová, Lenka (MBU-M)_ORCID Luptáková, Dominika (MBU-M)_{ORCID, RID} Pluháček, Tomáš (MBU-M)_ORCID Vannucci, Luca (MBU-M)_{RID, ORCID} Havlíček, Vladimír (MBU-M)_{RID, ORCID} Engstová, Hana (FGU-C)_{RID, ORCID} Jirák, D. (CZ) Šlouf, Miroslav (UMCH-V)_{RID, ORCID} Makovický, Peter (UMG-J) Sedláček, Radislav (UMG-J)_RID Horák, Daniel (UMCH-V)_{RID, ORCID}
Zdroj.dok.	RSC Advances. - : Royal Society of Chemistry Roč. 7, č. 73 (2017), s. 45997-46006
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	upconversion nanoparticles ; gadolinium ; tumor mouse
Vědní obor RIV	CD - Makromolekulární chemie
Obor OECD	Polymer science
Vědní obor RIV – spolupráce	Mikrobiologický ústav - Mikrobiologie, virologie Ústav molekulární genetiky - Onkologie a hematologie Fyziologický ústav - Ostatní materiály
CEP	GA15-01897S GA ČR - Grantová agentura ČR
	LD15135 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	TE01020118 GA TA ČR - Technologická agentura ČR
Institucionální podpora	UMCH-V - RVO:61389013 ; MBU-M - RVO:61388971 ; UMG-J - RVO:68378050 ; FGU-C - RVO:67985823
UT WOS	000412211300014
EID SCOPUS	85030655552
DOI	10.1039/C7RA08712H
Anotace	Nanoparticles are constructs that can be used for cellular interventions and targeted drug delivery. They are useful for overcoming the dose-related toxic effects of drugs or diagnostic preparations by predominant or selective accumulation in the pathologic tissues. Gadolinium(III) compounds are largely used as contrast agents in magnetic resonance imaging but may have toxic effects, especially in nephropathic patients, due to the dose required for use in MRI. Here, we describe the preparation of new multifunctional NaGdF4:Yb3+/Er3+ nanoparticles, their characteristic properties, and some preliminary data about their effect on cell viability and tissue localization. Hexagonal-phase NaGdF4 nanocrystals that were doped with optically active Yb3+ and Er3+ ions, were synthesized by coprecipitation of lanthanide chlorides in octadec-1-ene at high temperature, stabilized by oleic acid, and subsequently coated with a thin silica layer. The morphology, elemental composition, crystalline structure, and SiO2 coating of the prepared NaGdF4:Yb3+/Er3+@SiO2 nanoparticles were characterized in detail by transmission electron microscopy combined with energy-dispersive spectroscopy and selected area electron diffraction and attenuated total reflection Fourier transform infrared (ATR FTIR) spectroscopy. The upconversion and paramagnetic properties of the particles were measured using confocal microscopy and MRI, respectively. The biocompatibility of the NaGdF4:Yb3+/Er3+@SiO2 nanoparticles was tested in vitro using mouse 3T3 fibroblasts and B16F10 melanoma cells. Particle localization was evaluated ex vivo in tumor, liver, and brain tissues of B16F10 melanoma bearing mice after intravenous administration. The NaGdF4:Yb3+/Er3+@SiO2 particles proved to be non-toxic at moderate concentrations. Particle localization within the organs was demonstrated by analysis of the tissues using laser ablation inductively coupled plasma mass spectrometry and showed vascular localization.
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2018

Počet záznamů: 1