Počet záznamů: 1
Identification of a hybrid myocardial zone in the mammalian heart after birth
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SYSNO ASEP 0477526 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Identification of a hybrid myocardial zone in the mammalian heart after birth Tvůrce(i) Tian, X. (CN)
Li, Y. (CN)
He, L. (CN)
Zhang, H. (CN)
Huang, X. (CN)
Liu, Q. (CN)
Pu, W. (CN)
Zhang, LB. (CN)
Li, Yi. (CN)
Zhao, H. (CN)
Wang, Z. (CN)
Zhu, J. (CN)
Nie, Y. (CN)
Hu, S. (CN)
Sedmera, David (FGU-C) RID, ORCID, SAI
Zhong, T. P. (CN)
Yu, Y. (CN)
Zhang, L. (CN)
Yan, Y. (CN)
Qiao, Z. (CN)
Wang, Q-D. (SE)
Wu, S. M. (US)
Pu, W. T. (US)
Anderson, R. H. (GB)
Zhou, B. (CN)Číslo článku 87 Zdroj.dok. Nature Communications. - : Nature Publishing Group
Roč. 8, Jul 20 (2017)Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova left-ventricular noncompaction ; lineage tracing ; coronary-arteries ; cardiomyocyte proliferation ; gene-expression Vědní obor RIV EA - Morfologické obory a cytologie Obor OECD Anatomy and morphology (plant science to be 1.6) CEP GA13-12412S GA ČR - Grantová agentura ČR GA16-02972S GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 UT WOS 000405900400004 EID SCOPUS 85025436239 DOI 10.1038/s41467-017-00118-1 Anotace Noncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa(+) or Hey(2+) cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa(+) and Hey(2+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa(+) and Hey(2+) populations. Inhibition of the fetal Hey(2+) cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey(2+) fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2018
Počet záznamů: 1