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Identification of a hybrid myocardial zone in the mammalian heart after birth

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    SYSNO ASEP0477526
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevIdentification of a hybrid myocardial zone in the mammalian heart after birth
    Tvůrce(i) Tian, X. (CN)
    Li, Y. (CN)
    He, L. (CN)
    Zhang, H. (CN)
    Huang, X. (CN)
    Liu, Q. (CN)
    Pu, W. (CN)
    Zhang, LB. (CN)
    Li, Yi. (CN)
    Zhao, H. (CN)
    Wang, Z. (CN)
    Zhu, J. (CN)
    Nie, Y. (CN)
    Hu, S. (CN)
    Sedmera, David (FGU-C) RID, ORCID, SAI
    Zhong, T. P. (CN)
    Yu, Y. (CN)
    Zhang, L. (CN)
    Yan, Y. (CN)
    Qiao, Z. (CN)
    Wang, Q-D. (SE)
    Wu, S. M. (US)
    Pu, W. T. (US)
    Anderson, R. H. (GB)
    Zhou, B. (CN)
    Číslo článku87
    Zdroj.dok.Nature Communications
    Roč. 8, Jul 20 (2017)
    Poč.str.16 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaleft-ventricular noncompaction ; lineage tracing ; coronary-arteries ; cardiomyocyte proliferation ; gene-expression
    Vědní obor RIVEA - Morfologické obory a cytologie
    Obor OECDAnatomy and morphology (plant science to be 1.6)
    CEPGA13-12412S GA ČR - Grantová agentura ČR
    GA16-02972S GA ČR - Grantová agentura ČR
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000405900400004
    EID SCOPUS85025436239
    DOI10.1038/s41467-017-00118-1
    AnotaceNoncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa(+) or Hey(2+) cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa(+) and Hey(2+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa(+) and Hey(2+) populations. Inhibition of the fetal Hey(2+) cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey(2+) fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2018
Počet záznamů: 1