Počet záznamů: 1
The Impact of the Eda Pathway on Tooth Root Development.
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SYSNO ASEP 0477375 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The Impact of the Eda Pathway on Tooth Root Development. Tvůrce(i) Fons Romero, J.M. (GB)
Star, H. (GB)
Lav, R. (GB)
Watkins, S. (GB)
Harrison, M. (GB)
Hovořáková, Mária (UEM-P) RID
Headon, D. (GB)
Tucker, Abigail (UEM-P)Zdroj.dok. Journal of Dental Research. - : Sage - ISSN 0022-0345
Roč. 96, č. 11 (2017), s. 1290-1297Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova tooth ; ectodermal dysplasia ; epithelium Vědní obor RIV EA - Morfologické obory a cytologie Obor OECD Developmental biology CEP GB14-37368G GA ČR - Grantová agentura ČR Institucionální podpora UEM-P - RVO:68378041 UT WOS 000411431200014 EID SCOPUS 85029827753 DOI 10.1177/0022034517725692 Anotace The Eda pathway (Eda, Edar, Edaradd) plays an important role in tooth development, determining tooth number, crown shape, and enamel formation. Here we show that the Eda pathway also plays a key role in root development. Edar (the receptor) is expressed in Hertwig's epithelial root sheath (HERS) during root development, with mutant mice showing a high incidence of taurodontism: large pulp chambers lacking or showing delayed bifurcation or trifurcation of the roots. The mouse upper second molars in the Eda pathway mutants show the highest incidence of taurodontism, this enhanced susceptibility being matched in human patients with mutations in EDA-A1. These taurodont teeth form due to defects in the direction of extension of the HERS from the crown, associated with a more extensive area of proliferation of the neighboring root mesenchyme. In those teeth where the angle at which the HERS extends from the crown is very wide and therefore more vertical, the mutant HERSs fail to reach toward the center of the tooth in the normal furcation region, and taurodont teeth are created. The phenotype is variable, however, with milder changes in angle and proliferation leading to normal or delayed furcation. This is the first analysis of the role of Eda in the root, showing a direct role for this pathway during postnatal mouse development, and it suggests that changes in proliferation and angle of HERS may underlie taurodontism in a range of syndromes. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2018
Počet záznamů: 1