Počet záznamů: 1
Role of Primary Cilia in Odontogenesis
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SYSNO ASEP 0477095 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Role of Primary Cilia in Odontogenesis Tvůrce(i) Hampl, Marek (UZFG-Y) ORCID
Celá, Petra (UZFG-Y) RID
Szabo-Rogers, H. L. (US)
Kunová Bosáková, M. (CZ)
Dosedělová, Hana (UZFG-Y)
Krejčí, P. (CZ)
Buchtová, Marcela (UZFG-Y) RID, ORCIDZdroj.dok. Journal of Dental Research. - : Sage - ISSN 0022-0345
Roč. 96, č. 9 (2017), s. 965-974Poč.str. 10 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova craniofacial anomalies ; growth/development ; mineralized tissue/development Vědní obor RIV FF - ORL, oftalmologie, stomatologie Obor OECD Dentistry, oral surgery and medicine CEP EF15_003/0000460 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA17-14886S GA ČR - Grantová agentura ČR Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000406054800001 EID SCOPUS 85025612713 DOI 10.1177/0022034517713688 Anotace Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues. The cilia are present when interactions between both the epithelium and mesenchyme are required for normal morphogenesis. As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue-producing cells. Here, we summarize the current evidence for the localization of primary cilia in dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2018
Počet záznamů: 1