Počet záznamů: 1  

Axon tension regulates fasciculation/defasciculation through the control of axon shaft zippering

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    SYSNO ASEP0476688
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAxon tension regulates fasciculation/defasciculation through the control of axon shaft zippering
    Tvůrce(i) Šmít, Daniel (FGU-C)
    Fouquet, C. (FR)
    Pincet, F. (FR)
    Zápotocký, Martin (FGU-C) RID, ORCID
    Trembleau, A. (FR)
    Číslo článkue19907
    Zdroj.dok.eLife - ISSN 2050-084X
    Roč. 6, Apr 19 (2017)
    Poč.str.49 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovabiophysics ; cell adhesion ; coarsening ; developmental biology ; mathematical model ; mechanical tension ; axon guidance
    Vědní obor RIVBO - Biofyzika
    Obor OECDBiophysics
    CEPGA14-16755S GA ČR - Grantová agentura ČR
    7AMB12FR002 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000403786800001
    EID SCOPUS85021442510
    DOI10.7554/eLife.19907
    AnotaceWhile axon fasciculation plays a key role in the development of neural networks, very little is known about its dynamics and the underlying biophysical mechanisms. In a model system composed of neurons grown ex vivo from explants of embryonic mouse olfactory epithelia, we observed that axons dynamically interact with each other through their shafts, leading to zippering and unzippering behavior that regulates their fasciculation. Taking advantage of this new preparation suitable for studying such interactions, we carried out a detailed biophysical analysis of zippering, occurring either spontaneously or induced by micromanipulations and pharmacological treatments. We show that zippering arises from the competition of axon-axon adhesion and mechanical tension in the axons, and provide the first quantification of the force of axon-axon adhesion. Furthermore, we introduce a biophysical model of the zippering dynamics, and we quantitatively relate the individual zipper properties to global characteristics of the developing axon network. Our study uncovers a new role of mechanical tension in neural development: the regulation of axon fasciculation.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2018
Počet záznamů: 1