Počet záznamů: 1
Self-assembled chitosan-alginate polyplex nanoparticles containing temoporfin
- 1.
SYSNO ASEP 0476354 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Self-assembled chitosan-alginate polyplex nanoparticles containing temoporfin Tvůrce(i) Brezaniova, I. (CZ)
Trousil, Jiří (UMCH-V) RID, ORCID
Černochová, Zulfiya (UMCH-V) RID, ORCID
Král, V. (CZ)
Hrubý, Martin (UMCH-V) RID, ORCID
Štěpánek, Petr (UMCH-V) RID, ORCID
Šlouf, Miroslav (UMCH-V) RID, ORCIDZdroj.dok. Colloid and Polymer Science - ISSN 0303-402X
Roč. 295, č. 8 (2017), s. 1259-1270Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova chitosan ; sodium alginate ; temoporfin Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA16-02870S GA ČR - Grantová agentura ČR NV15-25781A GA MZd - Ministerstvo zdravotnictví LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000406174700002 EID SCOPUS 85008514396 DOI 10.1007/s00396-016-3992-6 Anotace The aim of this study was to develop biocompatible polyplex nanoparticles with physicochemical properties suitable for the delivery of photosensitizer temoporfin. We prepared, characterized, and compared the two types of polyplex nanoformulations consisting of sodium alginate in combination with chitosan polymer or chitosan oligomer lactate. We obtained the polyplex system by multiple electrostatic interactions between cationic chitosan and anionic alginate and identified key process parameters. Particle size distribution, dispersity, and zeta potential were determined by dynamic light scattering (DLS), and the diameter and the morphology of the individual particles were visualized by a transmission electron microscopy (TEM). It was found that size distribution of the polyplex nanoparticles depends on the concentrations of chitosan and alginate stock solutions and the order and ratio of addition of stock solutions as well as on the pH of the resulting mixture. It appears that the nanoparticles are homogeneous, although micrographs indicate some (vague, indistinct) core-shell structure. The nanoparticles are stable at pH 7.4 (pH of blood plasma) and show only very little drug leak in experiment modeling conditions of blood pool transport to target tissues. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2018
Počet záznamů: 1