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Plasma Phospholipid Fatty Acid Profile is Altered in Both Septic and Non-Septic Critically Ill: A Correlation with Inflammatory Markers and Albumin

SYSNO ASEP	0474690
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Plasma Phospholipid Fatty Acid Profile is Altered in Both Septic and Non-Septic Critically Ill: A Correlation with Inflammatory Markers and Albumin
Tvůrce(i)	Novák, F. (CZ) Borovská, J. (CZ) Vecka, M. (CZ) Rychlíková, J. (CZ) Vávrová, L. (CZ) Petrásková, H. (CZ) Žák, A. (CZ) Nováková, Olga (FGU-C)
Zdroj.dok.	Lipids. - : Wiley - ISSN 0024-4201 Roč. 52, č. 3 (2017), s. 245-254
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	sepsis ; inflammation ; oxidative stress ; plasma lipids ; fatty acid profile ; PUFA ; lipoproteins
Vědní obor RIV	FB - Endokrinologie, diabetologie, metabolizmus, výživa
Obor OECD	Critical care medicine and Emergency medicine
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000394999500005
EID SCOPUS	85007473579
DOI	10.1007/s11745-016-4226-x
Anotace	This study analyzes fatty acid (FA) composition in plasma lipids and erythrocyte phospholipids while comparing septic and non-septic critically ill patients. The aim was to describe impacts of infection and the inflammatory process. Patients with severe sepsis (SP, n = 13), age-, sex- and APACHE II score-matched non-septic critically ill with systemic inflammatory response syndrome (NSP, n = 13), and age-/sex-matched healthy controls (HC, n = 13) were included in a prospective case-control study during the first 24 h after admission to the intensive care unit. In both SP and NSP, lower n-6 polyunsaturated FA (PUFA) accompanied by higher proportions of monounsaturated FA (MUFA) in plasma phospholipids (PPL) was observed relative to HC. MUFA proportion was negatively correlated with n-6 PUFA, high density lipoprotein cholesterol (HDL-C), and albumin. MUFA was positively correlated with C-reactive protein (CRP), procalcitonin (PCT), interleukins (IL-6, IL-10), oxidized low density lipoproteins (ox-LDL), and conjugated dienes (CD). In both SP and NSP, inflammatory and lipid peroxidation markers were significantly higher-CRP (p < 0.001, p = 0.08), IL-6, IL-10, TNF-alpha (p < 0.01, p = 0.06), ox-LDL, and CD while total cholesterol, HDL-C, LDL-C albumin, and 20:4n-6/22:6n-3 and n-6/n-3 ratios were lower compared to HC. In conclusion, the changes in plasma lipid FA profile relate to the intensity of inflammatory and peroxidative response regardless of insult etiology. The lower MUFA and higher n-6 PUFA proportions in PPL were inversely correlated with cholesterol and albumin levels.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2018

Počet záznamů: 1