Počet záznamů: 1
Hyaluronan polymeric micelles for topical drug delivery
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SYSNO ASEP 0474586 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Hyaluronan polymeric micelles for topical drug delivery Tvůrce(i) Šmejkalová, D. (CZ)
Muthný, T. (CZ)
Nešporová, K. (CZ)
Hermannová, M. (CZ)
Achbergerová, E. (CZ)
Huerta-Angelesa, G. (CZ)
Marek Svoboda, M. (CZ)
Čepa, M. (CZ)
Machalová, V. (CZ)
Luptáková, Dominika (MBU-M) ORCID, RID
Velebný, V. (CZ)Zdroj.dok. Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 156, JAN 20 (2017), s. 86-96Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Skin penetration ; Polymeric micelle ; Hyaluronan Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology Institucionální podpora MBU-M - RVO:61388971 UT WOS 000388110900011 EID SCOPUS 84986286533 DOI 10.1016/j.carbpol.2016.09.013 Anotace Nanosized materials offer promising strategy for topical drug delivery due to their enhancing effect on drug percutaneous transport across the stratum corneum barrier. In this work, polymeric micelles made from hydrophobized hyaluronic acid (HA) were probed for skin delivery. Compared to non-polymeric micelle solutions containing similar drug amount, in vitro skin penetration analysis indicated 3 times larger deposition of drug in the epidermis and 6 times larger drug deposition in the dermis after 5 h of topical treatment in Franz diffusion cells. The drug deposition was further increased with prolonged time of topical treatment. Laser confocal microscopy revealed the accumulation of both, the HA forming the vehicle and the payload, in the epidermis and dermis. Although fluorescent labeling of the HA would suggest co-transport of the HA and the drug, loading FRET pair dyes in the micellar core clearly demonstrated gradual micelle disruption with increasing skin depth. Transcellular penetration was the predominant pathway for the loaded drug. The HA polymeric micelles also demonstrated increased bioactivity of loaded compound in vitro and in vivo. In addition, the loaded micelles were found to be stable in cream formulations and thus they have great potential for topical applications for cosmetic and pharmaceutical purposes. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2018
Počet záznamů: 1