Počet záznamů: 1
Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients
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SYSNO ASEP 0474103 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients Tvůrce(i) Stádníková, A. (CZ)
Ďuďáková, L. (CZ)
Skalická, P. (CZ)
Valenta, Zdeněk (UIVT-O) RID, SAI, ORCID
Filipec, M. (CZ)
Jirsová, K. (CZ)Číslo článku e0175509 Zdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 12, č. 4 (2017)Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova transforming growth factor-beta2 ; posterior polymorphous corneal dystrophy ; corneal endothelial cells ; general linear mixed-effect modelling ; restricted maximum likelihood estimation Vědní obor RIV BB - Aplikovaná statistika, operační výzkum Obor OECD Statistics and probability Institucionální podpora UIVT-O - RVO:67985807 UT WOS 000399874800030 EID SCOPUS 85017511236 DOI 10.1371/journal.pone.0175509 Anotace Posterior polymorphous corneal dystrophy (PPCD) is characterized by abnormal proliferation of corneal endothelial cells. It was shown that TGF-beta2 present in aqueous humor (AH) could help maintaining the corneal endothelium in a G1-phase-arrest state. We wanted to determine whether the levels of this protein are changed in AH of PPCD patients. The level of active TGF-beta2 in the AH of all PPCD patients (mean +/- SD, 386.98 +/- 114.88 pg/ml) in comparison to the control group (260.95 +/- 112.43 pg/ml) was significantly higher (P = 0.0001). Compared to the control group, a significantly higher level of active TGF- beta2 was found in the PPCD1 (P = 0.0005) and PPCDx (P = 0.0022) groups. Levels of active TGF- beta2 were not significantly affected by gender, age, secondary glaucoma or by the progression of dystrophy when one or repeated PK were performed. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2018
Počet záznamů: 1