Počet záznamů: 1

Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension

SYSNO ASEP	0473932
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension
Tvůrce(i)	Behuliak, Michal (FGU-C)_{RID, ORCID} Bencze, Michal (FGU-C)_{RID, ORCID, SAI} Vaněčková, Ivana (FGU-C)_{RID, ORCID} Kuneš, Jaroslav (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI}
Číslo článku	8029728
Zdroj.dok.	BioMed Research International. - : Hindawi - ISSN 2314-6133 Roč. 2017, January (2017)
Poč.str.	13 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	calcium sensitization ; RhoA/Rho kinase ; fasudil ; calcium influx ; nifedipine ; BAY K8644
Vědní obor RIV	FA - Kardiovaskulární nemoci vč. kardiochirurgie
Obor OECD	Cardiac and Cardiovascular systems
CEP	GP14-16225P GA ČR - Grantová agentura ČR
	NV15-25396A GA MZd - Ministerstvo zdravotnictví
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000394007500001
EID SCOPUS	85011931119
DOI	10.1155/2017/8029728
Anotace	Calcium sensitization mediated by RhoA/Rho kinase pathway can be evaluated either in the absence (basal calcium sensitization) or in the presence of endogenous vasoconstrictor systems (activated calcium sensitization). Our aim was to compare basal and activated calcium sensitization in three forms of experimental hypertension with increased sympathetic tone and enhanced calcium entry—spontaneously hypertensive rats (SHR), heterozygous Ren-2 transgenic rats (TGR), and salt hypertensive Dahl rats. Activated calcium sensitization was determined as blood pressure reduction induced by acute administration of Rho kinase inhibitor fasudil in conscious rats with intact sympathetic nervous system (SNS) and renin-angiotensin system (RAS). Basal calcium sensitization was studied as fasudil-dependent difference in blood pressure response to calcium channel opener BAY K8644 in rats subjected to RAS and SNS blockade. Calcium sensitization was also estimated from reduced development of isolated artery contraction by Rho kinase inhibitor Y-27632. Activated calcium sensitization was enhanced in all three hypertensive models (due to the hyperactivity of vasoconstrictor systems). In contrast, basal calcium sensitization was reduced in SHR and TGR relative to their controls, whereas it was augmented in salt-sensitive Dahl rats relative to their salt-resistant controls. Similar differences in calcium sensitization were seen in femoral arteries of SHR and Dahl rats.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2018

Počet záznamů: 1