Počet záznamů: 1
Identification of New World Quails Susceptible to Infection with Avian Leukosis Virus Subgroup J
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SYSNO ASEP 0473165 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Identification of New World Quails Susceptible to Infection with Avian Leukosis Virus Subgroup J Tvůrce(i) Plachý, Jiří (UMG-J) RID
Reinišová, Markéta (UMG-J)
Kučerová, Dana (UMG-J)
Šenigl, Filip (UMG-J) RID
Stepanets, Volodymyr (UMG-J) RID
Hron, Tomáš (UMG-J)
Trejbalová, Kateřina (UMG-J) RID
Elleder, Daniel (UMG-J) RID
Hejnar, Jiří (UMG-J) RIDCelkový počet autorů 9 Číslo článku e02002 Zdroj.dok. Journal of Virology - ISSN 0022-538X
Roč. 91, č. 3 (2017)Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova ALV-J ; antiretroviral resistance ; Na+/H+ exchanger ; New World quail ; retroviral receptor Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Virology CEP GA13-30983S GA ČR - Grantová agentura ČR LO1419 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMG-J - RVO:68378050 UT WOS 000393194600025 DOI 10.1128/JVI.02002-16 Anotace The J subgroup of avian leukosis virus (ALV-J) infects domestic chickens, jungle fowl, and turkeys. This virus enters the host cell through a receptor encoded by the tvj locus and identified as Na+/H+ exchanger 1. The resistance to avian leukosis virus subgroup J in a great majority of galliform species has been explained by deletions or substitutions of the critical tryptophan 38 in the first extracellular loop of Na+/H+ exchanger 1. Because there are concerns of transspecies virus transmission, we studied natural polymorphisms and susceptibility/resistance in wild galliforms and found the presence of tryptophan 38 in four species of New World quails. The embryo fibroblasts of New World quails are susceptible to infection with avian leukosis virus subgroup J, and the cloned Na+/H+ exchanger 1 confers susceptibility on the otherwise resistant host. New World quails are also susceptible to new avian leukosis virus subgroup J variants but resistant to subgroups A and B and weakly susceptible to subgroups C and D of avian sarcoma/leukosis virus due to obvious defects of the respective receptors. Our results suggest that the avian leukosis virus subgroup J could be transmitted to New World quails and establish a natural reservoir of circulating virus with a potential for further evolution. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2017
Počet záznamů: 1