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The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma
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SYSNO ASEP 0471894 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma Tvůrce(i) Paulenda, Tomáš (UMG-J)
Dráber, Petr (UMG-J) RIDCelkový počet autorů 2 Zdroj.dok. Allergy. - : Wiley - ISSN 0105-4538
Roč. 71, č. 7 (2016), s. 918-930Poč.str. 23 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova asthma ; cellular membranes ; endoplasmic ; reticulum ; ORMDL3 ; sphingolipids Vědní obor RIV EB - Genetika a molekulární biologie CEP GA14-00703S GA ČR - Grantová agentura ČR GA14-09807S GA ČR - Grantová agentura ČR GBP302/12/G101 GA ČR - Grantová agentura ČR Institucionální podpora UMG-J - RVO:68378050 UT WOS 000378280200002 DOI 10.1111/all.12877 Anotace A family of widely expressed ORM-like (ORMDL) proteins has been recently linked to asthma in genomewide association studies in humans and extensively explored in in vivo studies in mice. ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the initial step of sphingolipid biosynthesis. Sphingolipids play prominent roles in cell signaling and response to stress, and they affect the mechanistic properties of cellular membranes. Deregulation of sphingolipid biosynthesis and their recycling has been proven to support and even cause several diseases including allergy, inflammation, and asthma. ORMDL3, the most extensively studied member of the ORMDL family, has been shown to be important for endoplasmic reticulum homeostasis by regulating the unfolded protein response and calcium response. In immune cells, ORMDL3 is involved in migration and in the production of proinflammatory cytokines. Furthermore, changes in the expression level of ORMDL3 are important in allergen-induced asthma pathologies. This review focuses on functional aspects of the ORMDL family proteins, which may serve as new therapeutic targets for the treatment of asthma and some other life-threatening diseases. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2017
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