Počet záznamů: 1  

The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma

  1. 1.
    SYSNO ASEP0471894
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevThe role of ORMDL proteins, guardians of cellular sphingolipids, in asthma
    Tvůrce(i) Paulenda, Tomáš (UMG-J)
    Dráber, Petr (UMG-J) RID
    Celkový počet autorů2
    Zdroj.dok.Allergy. - : Wiley - ISSN 0105-4538
    Roč. 71, č. 7 (2016), s. 918-930
    Poč.str.23 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaasthma ; cellular membranes ; endoplasmic ; reticulum ; ORMDL3 ; sphingolipids
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEPGA14-00703S GA ČR - Grantová agentura ČR
    GA14-09807S GA ČR - Grantová agentura ČR
    GBP302/12/G101 GA ČR - Grantová agentura ČR
    Institucionální podporaUMG-J - RVO:68378050
    UT WOS000378280200002
    DOI10.1111/all.12877
    AnotaceA family of widely expressed ORM-like (ORMDL) proteins has been recently linked to asthma in genomewide association studies in humans and extensively explored in in vivo studies in mice. ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the initial step of sphingolipid biosynthesis. Sphingolipids play prominent roles in cell signaling and response to stress, and they affect the mechanistic properties of cellular membranes. Deregulation of sphingolipid biosynthesis and their recycling has been proven to support and even cause several diseases including allergy, inflammation, and asthma. ORMDL3, the most extensively studied member of the ORMDL family, has been shown to be important for endoplasmic reticulum homeostasis by regulating the unfolded protein response and calcium response. In immune cells, ORMDL3 is involved in migration and in the production of proinflammatory cytokines. Furthermore, changes in the expression level of ORMDL3 are important in allergen-induced asthma pathologies. This review focuses on functional aspects of the ORMDL family proteins, which may serve as new therapeutic targets for the treatment of asthma and some other life-threatening diseases.
    PracovištěÚstav molekulární genetiky
    KontaktNikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
    Rok sběru2017
Počet záznamů: 1  

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